TY - JOUR
T1 - Down-Regulated Calcium-Sensing Receptor in Keratinocytes and Skin from Aged Mice and Humans Impairs Function
AU - Bollag, Wendy B.
N1 - Publisher Copyright:
© 2021
PY - 2021/11
Y1 - 2021/11
N2 - The calcium-sensing receptor (CaSR) is important in the skin, contributing to several epidermal functions, including differentiation, water permeability barrier repair, and wound healing. Celli et al. (2021) show that CaSR levels are reduced in keratinocytes/skin from aged individuals, with resulting impairment of key functions. CaSR agonists can correct these defects, suggesting a possible therapy to combat aging-related delayed skin wound healing.
AB - The calcium-sensing receptor (CaSR) is important in the skin, contributing to several epidermal functions, including differentiation, water permeability barrier repair, and wound healing. Celli et al. (2021) show that CaSR levels are reduced in keratinocytes/skin from aged individuals, with resulting impairment of key functions. CaSR agonists can correct these defects, suggesting a possible therapy to combat aging-related delayed skin wound healing.
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U2 - 10.1016/j.jid.2021.04.005
DO - 10.1016/j.jid.2021.04.005
M3 - Comment/debate
C2 - 34688406
AN - SCOPUS:85116876530
SN - 0022-202X
VL - 141
SP - 2558
EP - 2561
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 11
ER -