Duration of the suppressive effect of tricyclic antidepressants on histamine-induced wheal-and-flare reactions in human skin

Kamineni S. Rao, Prem K. Menon, Bettina C. Hilman, C Simon Sebastian, Lee Bairnsfather

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The antihistaminic properties of the tricyclic antidepressants have been recognized since these compounds were first developed. Antidepressants, which are equally effective for treating depression or used in the treatment of chronic urticaria, have varying in vitro antihistaminic properties. We compared the duration of H1-receptor blockade by two tricyclic antidepressants, doxepin (the most potent antihistamine) and desipramine (the least potent antihistamine), in a single dose, double-blind, noncrossover study. After baseline prick test with histamine phosphate 1:1000 by Multitest (Lincoln Diagnostics, Decatur, Ill.), the suppression of cutaneous histamine-induced wheal-and-flare responses were measured daily for 7 days in 33 healthy volunteers who were randomly administered a single 25 mg dose of oral desipramine or doxepin. Significant differences in the suppression of the wheal-and-flare responses to histamine between the two drugs were noted (p < 0.05) during the first 3 days. Desipramine suppressed the wheal for 2 days and flare for 1 day. Doxepin suppressed the wheal for 4 days and flare for 6 days. Our results suggest doxepin should be withheld for at least 7 days before allergy skin testing.

Original languageEnglish (US)
Pages (from-to)752-757
Number of pages6
JournalThe Journal of allergy and clinical immunology
Volume82
Issue number5 PART 1
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

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Doxepin
Tricyclic Antidepressive Agents
Histamine
Desipramine
Skin
Histamine Antagonists
Histamine H1 Receptors
Urticaria
Double-Blind Method
Antidepressive Agents
Healthy Volunteers
Hypersensitivity
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Duration of the suppressive effect of tricyclic antidepressants on histamine-induced wheal-and-flare reactions in human skin. / Rao, Kamineni S.; Menon, Prem K.; Hilman, Bettina C.; Sebastian, C Simon; Bairnsfather, Lee.

In: The Journal of allergy and clinical immunology, Vol. 82, No. 5 PART 1, 01.01.1988, p. 752-757.

Research output: Contribution to journalArticle

Rao, Kamineni S. ; Menon, Prem K. ; Hilman, Bettina C. ; Sebastian, C Simon ; Bairnsfather, Lee. / Duration of the suppressive effect of tricyclic antidepressants on histamine-induced wheal-and-flare reactions in human skin. In: The Journal of allergy and clinical immunology. 1988 ; Vol. 82, No. 5 PART 1. pp. 752-757.
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