Early adrenarche in normal prepubertal girls: A prospective longitudinal study

Ricardo Azziz, Lisa A. Farah, Carlos Moran, Eric S. Knochenhauer, H. Downing Potter, Larry R. Boots

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: To study basal and ACTH stimulated levels of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4), and cortisol (F) in healthy girls during prepuberty. Patients: Six prepubertal girls, ages 3.7-10.9 years. Study Design and Measurements: The six girls underwent a physical examination and an acute ACTH stimulation test on a yearly basis. Serum DHEA, DHEAS, A4, and F at 0 min (Steroid0) and 60 min (Steroid60) after 0.25 mg ACTH1-24 i.v., and the net increment (ΔSteroid60-0) were calculated. Results: DHEAS0, DHEAS60, DHEA0, DHEA60 and A40 were positively correlated to chronological age. DHEAS0 and DHEAS60 levels rose gradually beginning at 6.1-7.0 years of chronological age, and were found to be significantly different at 9.1-10.0 years and 10.1-11.0 years of age, compared to the median values obtained at ≤6.0 years of age. There was a tendency for DHEA0, DHEA60, and A40 to increase beginning at 9.1-10.0 years of age. Net increment values of all hormones did not change throughout the study. Conclusion: An increase in the circulating level of DHEAS appears to be the first event observed during adrenarche, prior to clinical evidence of the process.

Original languageEnglish (US)
Pages (from-to)1231-1237
Number of pages7
JournalJournal of Pediatric Endocrinology and Metabolism
Volume17
Issue number9
DOIs
StatePublished - Jan 1 2004

Fingerprint

Adrenarche
Dehydroepiandrosterone Sulfate
Longitudinal Studies
Dehydroepiandrosterone
Prospective Studies
Adrenocorticotropic Hormone
Androstenedione
Physical Examination
Hydrocortisone
Hormones
Serum

Keywords

  • Adrenal
  • Adrenarche
  • Androgens
  • Dehydroepiandrosterone sulfate
  • Puberty

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Azziz, R., Farah, L. A., Moran, C., Knochenhauer, E. S., Potter, H. D., & Boots, L. R. (2004). Early adrenarche in normal prepubertal girls: A prospective longitudinal study. Journal of Pediatric Endocrinology and Metabolism, 17(9), 1231-1237. https://doi.org/10.1515/JPEM.2004.17.9.1231

Early adrenarche in normal prepubertal girls : A prospective longitudinal study. / Azziz, Ricardo; Farah, Lisa A.; Moran, Carlos; Knochenhauer, Eric S.; Potter, H. Downing; Boots, Larry R.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 17, No. 9, 01.01.2004, p. 1231-1237.

Research output: Contribution to journalArticle

Azziz, R, Farah, LA, Moran, C, Knochenhauer, ES, Potter, HD & Boots, LR 2004, 'Early adrenarche in normal prepubertal girls: A prospective longitudinal study', Journal of Pediatric Endocrinology and Metabolism, vol. 17, no. 9, pp. 1231-1237. https://doi.org/10.1515/JPEM.2004.17.9.1231
Azziz, Ricardo ; Farah, Lisa A. ; Moran, Carlos ; Knochenhauer, Eric S. ; Potter, H. Downing ; Boots, Larry R. / Early adrenarche in normal prepubertal girls : A prospective longitudinal study. In: Journal of Pediatric Endocrinology and Metabolism. 2004 ; Vol. 17, No. 9. pp. 1231-1237.
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