Early Clinical Signs Identify Low-Risk Patients With Acute Upper Gastrointestinal Hemorrhage

Donald R. Bordley, Alvin I. Mushlin, James G. Dolan, W. Scott Richardson, Michael Barry, John Polio, Paul F. Griner

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Early identification of patients at low risk for poor outcome after acute upper gastrointestinal hemorrhage would allow reduction of diagnostic and therapeutic interventions. We identified six early predictors of good outcome: age less than 75 years, no unstable comorbid illness, no ascites found on physical examination, normal prothrombin time, and, within an hour after presentation, systolic blood pressure of 100 mm Hg or greater and nasogastric aspirate free of fresh blood. Presence of all six predictors defined the low-risk population. Among 162 patients in the development and retrospective validation phases of our study, all 74 low-risk patients had good outcomes. A prospective validation study of 111 patients further established the accuracy of our predictive method; only two of 52 low-risk patients had poor outcomes. Application of our method should allow more selective management of patients with acute upper gastrointestinal hemorrhage.

Original languageEnglish (US)
Pages (from-to)3282-3285
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Issue number22
StatePublished - Jun 14 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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