Early Ultra structural Findings in Experimentally Produced Varicocele in the Monkey Testis

E. N. FUSSELL, Ronald W Lewis, JAMES A. ROBERTS, RICHARD M. HARRISON

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Varicocele was produced in adult male macaque monkeys (Macaca fascicularls) by partial occlusion of the left renal vein. Left varicoceie was verified by palpation. An increase In temperature of the left testicle was noted. Bilateral testicular biopsies were obtained at six, nine, and 18‐month intervals for morphologic studies. Early morphologic damage was not appreciated with the light microscope, but was found using transmission electron microscopy. The early ultrastructural damage consisted of loss in thickness and lamination of the basal lamina, cellular organelie degeneration, and enlargement of the intercellular spaces between basal cells of the seminiferous tubules. Later, ultrastructural damage was seen in the adluminal areas. At 18 months, ultrastructural damage had progressed to the right testis. Reflux of adrenal metabolites had no effect on the early ultrastructural damage. 1981 American Society of Andrology

Original languageEnglish (US)
Pages (from-to)111-119
Number of pages9
JournalJournal of Andrology
Volume2
Issue number2
DOIs
StatePublished - Jan 1 1981

Fingerprint

Varicocele
Macaca
Haplorhini
Testis
Seminiferous Tubules
Renal Veins
Palpation
Extracellular Space
Transmission Electron Microscopy
Basement Membrane
Biopsy
Light
Temperature

Keywords

  • adrenal metabolites
  • electron microscopy
  • monkey
  • testicular morphology
  • varicocele

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Urology

Cite this

Early Ultra structural Findings in Experimentally Produced Varicocele in the Monkey Testis. / FUSSELL, E. N.; Lewis, Ronald W; ROBERTS, JAMES A.; HARRISON, RICHARD M.

In: Journal of Andrology, Vol. 2, No. 2, 01.01.1981, p. 111-119.

Research output: Contribution to journalArticle

FUSSELL, E. N. ; Lewis, Ronald W ; ROBERTS, JAMES A. ; HARRISON, RICHARD M. / Early Ultra structural Findings in Experimentally Produced Varicocele in the Monkey Testis. In: Journal of Andrology. 1981 ; Vol. 2, No. 2. pp. 111-119.
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