Effect of age on gingival crevicular fluid concentrations of MIF and PGE2

C. Nonnenmacher, K. Helms, M. Bacher, R. M. Nüsing, Cristiano Susin, R. Mutters, L. Flores-de-Jacoby, R. Mengel

Research output: Contribution to journalArticle

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Abstract

We used an experimental gingivitis study design to compare crevicular fluid concentrations of Migration Inhibitory Factor (MIF) and Prostaglandin E 2(PGE2) in younger (18 to 30 yrs) and older (46 to 77 yrs) healthy adults. PGE2 increased after 1 wk in younger participants, whereas it decreased in older individuals after 1 wk of plaque accumulation. A significant interaction between age and time was observed for PGE2 (p = 0.04). High concentrations of MIF were identified in both age groups at baseline. MIF increased in the younger participants, whereas in the older individuals a decrease over time was observed. MIF concentration was positively correlated with plaque index and gingival index in the older age group. Total counts of bacteria, Parvimonas micra and Prevotella intermedia, were significantly correlated with MIF concentration in older participants. In conclusion, MIF and PGE2 production in response to bacterial accumulation seems to be modified by age.

Original languageEnglish (US)
Pages (from-to)639-643
Number of pages5
JournalJournal of Dental Research
Volume88
Issue number7
DOIs
StatePublished - Jul 1 2009

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Gingival Crevicular Fluid
Prostaglandins E
Age Groups
Prevotella intermedia
Periodontal Index
Gingivitis
Bacteria

Keywords

  • Age
  • Experimental gingivitis
  • MIF
  • PGE
  • Real-time PCR

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Nonnenmacher, C., Helms, K., Bacher, M., Nüsing, R. M., Susin, C., Mutters, R., ... Mengel, R. (2009). Effect of age on gingival crevicular fluid concentrations of MIF and PGE2. Journal of Dental Research, 88(7), 639-643. https://doi.org/10.1177/0022034509340148

Effect of age on gingival crevicular fluid concentrations of MIF and PGE2. / Nonnenmacher, C.; Helms, K.; Bacher, M.; Nüsing, R. M.; Susin, Cristiano; Mutters, R.; Flores-de-Jacoby, L.; Mengel, R.

In: Journal of Dental Research, Vol. 88, No. 7, 01.07.2009, p. 639-643.

Research output: Contribution to journalArticle

Nonnenmacher, C, Helms, K, Bacher, M, Nüsing, RM, Susin, C, Mutters, R, Flores-de-Jacoby, L & Mengel, R 2009, 'Effect of age on gingival crevicular fluid concentrations of MIF and PGE2', Journal of Dental Research, vol. 88, no. 7, pp. 639-643. https://doi.org/10.1177/0022034509340148
Nonnenmacher C, Helms K, Bacher M, Nüsing RM, Susin C, Mutters R et al. Effect of age on gingival crevicular fluid concentrations of MIF and PGE2. Journal of Dental Research. 2009 Jul 1;88(7):639-643. https://doi.org/10.1177/0022034509340148
Nonnenmacher, C. ; Helms, K. ; Bacher, M. ; Nüsing, R. M. ; Susin, Cristiano ; Mutters, R. ; Flores-de-Jacoby, L. ; Mengel, R. / Effect of age on gingival crevicular fluid concentrations of MIF and PGE2. In: Journal of Dental Research. 2009 ; Vol. 88, No. 7. pp. 639-643.
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