@article{0801af3ccd8c4594870e93d278b65d98,
title = "Effect of calcium deprivation and calcium overload on the sarcolemmal lipid bilayer",
author = "M. Ashraf",
note = "Funding Information: ADAPTIVE GROWTH OF RAT PAPILLARY MUSCLE. P. Anversa, G.Olivetti, Melissari and A.V. Loud. Departments of Pathology, Parma, Italy, York Medical College, Valhalla, New York. The papillary muscle, 8 days after a 64% constriction of the abdominal aorta, showed a 51% overall volume hypertrophy. The contribution of different cellular and extracellular structures to this hypertrophy was evaluated from the morphometric measurements of their volume percentages. In addition, the mean cell volumes of endothelial cells, connective tissue cells and myocytes were estimated by nuclear counting in sections of different known thicknesses. Combining these two methods, the degree of cellular hypertrophy and hyperplasia was calculated. The mean volume of endothelial cells was increased by a 34% average hypertrophy. In order to account for the doubled endothelial volume of the total population the remaining increment was represented by a 48% hyperplasia. Similarly, the average cell volume among the connective tissue cells was found to be increased by 64% and the number of such cells increased by 35%. In the contractile cell population the mean volume myocytes was 53% greater but there was no indication of hyperplasia. Although, it is well established that adult myocardial hypertrophy includes hyperplasia among interstitial cell populations and only hypertrophy of the myocytes, the present study provides a numerical characterization of these phenomena. (Supported by Grants from the CNR Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "1978",
doi = "10.1016/0022-2828(78)90050-0",
language = "English (US)",
volume = "10",
pages = "3",
journal = "Journal of Molecular and Cellular Cardiology",
issn = "0022-2828",
publisher = "Academic Press Inc.",
number = "SUPPL.1",
}