Effect of carbodiimide on the fatigue crack growth resistance of resin-dentin bonds

Zihou Zhang, Dylan Beitzel, Hessam Majd, Mustafa Mutluay, Arzu Tezvergil-Mutluay, Franklin Chi Meng Tay, David Henry Pashley, Dwayne Arola

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Recent studies have shown that ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) inactivates endogenous dentin proteases, thereby preventing collagen degradation and improving the durability of adhesive bonds to dentin. Bond durability is routinely assessed by monotonic microtensile testing, which does not consider the cyclic nature of mastication. Objective To characterize the effect of an EDC pretreatment on the fatigue crack growth behavior of resin-dentin bonds. Methods Bonded interface Compact Tension (CT) specimens were prepared using a three-step etch-and-rinse adhesive and hybrid resin-composite. Adhesive bonding of the treated groups included a 1 min application of an experimental EDC conditioner to the acid-etched dentin. The control groups did not receive EDC treatment. The fatigue crack growth resistance was examined after storage in artificial saliva for 0, 3 and 6 months. Results There was no significant difference in the immediate fatigue crack growth resistance of the EDC-treated and control groups at 0 months. However, after the 3 and 6 months storage periods the EDC-treated groups exhibited significantly greater (p ≤ 0.05) fatigue crack growth resistance than the control specimens. Significance Although the EDC treatment maintained the fatigue crack growth resistance of the dentin bonds through 6 months of storage, additional studies are needed to assess its effectiveness over longer periods and in relation to other cross-linking agents.

Original languageEnglish (US)
Pages (from-to)211-222
Number of pages12
JournalDental Materials
Volume32
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Carbodiimides
Dentin
Fatigue crack propagation
Fatigue
Resins
Adhesives
Growth
Durability
Artificial Saliva
Mastication
Control Groups
Composite Resins
Collagen
Peptide Hydrolases
Degradation
Acids
Composite materials
Testing

Keywords

  • Collagen
  • Cross-linker
  • Dentin bonding agents
  • Durability
  • EDC
  • Endogenous proteinases
  • Fatigue crack growth
  • Fracture

ASJC Scopus subject areas

  • Materials Science(all)
  • Dentistry(all)
  • Mechanics of Materials

Cite this

Zhang, Z., Beitzel, D., Majd, H., Mutluay, M., Tezvergil-Mutluay, A., Tay, F. C. M., ... Arola, D. (2016). Effect of carbodiimide on the fatigue crack growth resistance of resin-dentin bonds. Dental Materials, 32(2), 211-222. https://doi.org/10.1016/j.dental.2015.11.024

Effect of carbodiimide on the fatigue crack growth resistance of resin-dentin bonds. / Zhang, Zihou; Beitzel, Dylan; Majd, Hessam; Mutluay, Mustafa; Tezvergil-Mutluay, Arzu; Tay, Franklin Chi Meng; Pashley, David Henry; Arola, Dwayne.

In: Dental Materials, Vol. 32, No. 2, 01.02.2016, p. 211-222.

Research output: Contribution to journalArticle

Zhang, Z, Beitzel, D, Majd, H, Mutluay, M, Tezvergil-Mutluay, A, Tay, FCM, Pashley, DH & Arola, D 2016, 'Effect of carbodiimide on the fatigue crack growth resistance of resin-dentin bonds', Dental Materials, vol. 32, no. 2, pp. 211-222. https://doi.org/10.1016/j.dental.2015.11.024
Zhang, Zihou ; Beitzel, Dylan ; Majd, Hessam ; Mutluay, Mustafa ; Tezvergil-Mutluay, Arzu ; Tay, Franklin Chi Meng ; Pashley, David Henry ; Arola, Dwayne. / Effect of carbodiimide on the fatigue crack growth resistance of resin-dentin bonds. In: Dental Materials. 2016 ; Vol. 32, No. 2. pp. 211-222.
@article{7f63fe1109f54aeb8c3c3281cb2b4442,
title = "Effect of carbodiimide on the fatigue crack growth resistance of resin-dentin bonds",
abstract = "Recent studies have shown that ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) inactivates endogenous dentin proteases, thereby preventing collagen degradation and improving the durability of adhesive bonds to dentin. Bond durability is routinely assessed by monotonic microtensile testing, which does not consider the cyclic nature of mastication. Objective To characterize the effect of an EDC pretreatment on the fatigue crack growth behavior of resin-dentin bonds. Methods Bonded interface Compact Tension (CT) specimens were prepared using a three-step etch-and-rinse adhesive and hybrid resin-composite. Adhesive bonding of the treated groups included a 1 min application of an experimental EDC conditioner to the acid-etched dentin. The control groups did not receive EDC treatment. The fatigue crack growth resistance was examined after storage in artificial saliva for 0, 3 and 6 months. Results There was no significant difference in the immediate fatigue crack growth resistance of the EDC-treated and control groups at 0 months. However, after the 3 and 6 months storage periods the EDC-treated groups exhibited significantly greater (p ≤ 0.05) fatigue crack growth resistance than the control specimens. Significance Although the EDC treatment maintained the fatigue crack growth resistance of the dentin bonds through 6 months of storage, additional studies are needed to assess its effectiveness over longer periods and in relation to other cross-linking agents.",
keywords = "Collagen, Cross-linker, Dentin bonding agents, Durability, EDC, Endogenous proteinases, Fatigue crack growth, Fracture",
author = "Zihou Zhang and Dylan Beitzel and Hessam Majd and Mustafa Mutluay and Arzu Tezvergil-Mutluay and Tay, {Franklin Chi Meng} and Pashley, {David Henry} and Dwayne Arola",
year = "2016",
month = "2",
day = "1",
doi = "10.1016/j.dental.2015.11.024",
language = "English (US)",
volume = "32",
pages = "211--222",
journal = "Dental Materials",
issn = "0109-5641",
publisher = "Elsevier Science",
number = "2",

}

TY - JOUR

T1 - Effect of carbodiimide on the fatigue crack growth resistance of resin-dentin bonds

AU - Zhang, Zihou

AU - Beitzel, Dylan

AU - Majd, Hessam

AU - Mutluay, Mustafa

AU - Tezvergil-Mutluay, Arzu

AU - Tay, Franklin Chi Meng

AU - Pashley, David Henry

AU - Arola, Dwayne

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Recent studies have shown that ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) inactivates endogenous dentin proteases, thereby preventing collagen degradation and improving the durability of adhesive bonds to dentin. Bond durability is routinely assessed by monotonic microtensile testing, which does not consider the cyclic nature of mastication. Objective To characterize the effect of an EDC pretreatment on the fatigue crack growth behavior of resin-dentin bonds. Methods Bonded interface Compact Tension (CT) specimens were prepared using a three-step etch-and-rinse adhesive and hybrid resin-composite. Adhesive bonding of the treated groups included a 1 min application of an experimental EDC conditioner to the acid-etched dentin. The control groups did not receive EDC treatment. The fatigue crack growth resistance was examined after storage in artificial saliva for 0, 3 and 6 months. Results There was no significant difference in the immediate fatigue crack growth resistance of the EDC-treated and control groups at 0 months. However, after the 3 and 6 months storage periods the EDC-treated groups exhibited significantly greater (p ≤ 0.05) fatigue crack growth resistance than the control specimens. Significance Although the EDC treatment maintained the fatigue crack growth resistance of the dentin bonds through 6 months of storage, additional studies are needed to assess its effectiveness over longer periods and in relation to other cross-linking agents.

AB - Recent studies have shown that ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) inactivates endogenous dentin proteases, thereby preventing collagen degradation and improving the durability of adhesive bonds to dentin. Bond durability is routinely assessed by monotonic microtensile testing, which does not consider the cyclic nature of mastication. Objective To characterize the effect of an EDC pretreatment on the fatigue crack growth behavior of resin-dentin bonds. Methods Bonded interface Compact Tension (CT) specimens were prepared using a three-step etch-and-rinse adhesive and hybrid resin-composite. Adhesive bonding of the treated groups included a 1 min application of an experimental EDC conditioner to the acid-etched dentin. The control groups did not receive EDC treatment. The fatigue crack growth resistance was examined after storage in artificial saliva for 0, 3 and 6 months. Results There was no significant difference in the immediate fatigue crack growth resistance of the EDC-treated and control groups at 0 months. However, after the 3 and 6 months storage periods the EDC-treated groups exhibited significantly greater (p ≤ 0.05) fatigue crack growth resistance than the control specimens. Significance Although the EDC treatment maintained the fatigue crack growth resistance of the dentin bonds through 6 months of storage, additional studies are needed to assess its effectiveness over longer periods and in relation to other cross-linking agents.

KW - Collagen

KW - Cross-linker

KW - Dentin bonding agents

KW - Durability

KW - EDC

KW - Endogenous proteinases

KW - Fatigue crack growth

KW - Fracture

UR - http://www.scopus.com/inward/record.url?scp=84957846091&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957846091&partnerID=8YFLogxK

U2 - 10.1016/j.dental.2015.11.024

DO - 10.1016/j.dental.2015.11.024

M3 - Article

VL - 32

SP - 211

EP - 222

JO - Dental Materials

JF - Dental Materials

SN - 0109-5641

IS - 2

ER -