Effect of indomethacin on cerebral blood flow and development of oxygen convulsions

A. N. Moskvin, O. S. Alekseeva, D. R. Gutsaeva, A. V. Khmel'nitskii, O. I. Sharapov

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Hyperbaric oxygenation modulates cerebral blood flow affecting the development of oxygen convulsions. Before hyperbaric oxygenation-induced convulsions in rats the initial decrease in blood flow gave place to hyperemia, Po2 increased. In rats receiving cyclooxygenase inhibitor indomethacin no convulsions were observed, blood flow and Po2 were lower than in controls. Our results indicate that indomethacin prevents hyperemia and alleviates oxygen convulsions under conditions of hyperbaric oxygenation.

Original languageEnglish (US)
Pages (from-to)26-28
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume142
Issue number1
DOIs
StatePublished - Jul 1 2006
Externally publishedYes

Keywords

  • Cerebral blood flow
  • Cyclooxygenase
  • Hyperbaric oxygenation
  • Indomethacin
  • Oxygen convulsions

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Effect of indomethacin on cerebral blood flow and development of oxygen convulsions'. Together they form a unique fingerprint.

  • Cite this