Effect of LTP-reinforcing paradigms on neurotransmitter release in the dentate gyrus of young and aged rats

W. Almaguer-Melian, R. Cruz-Aguado, C. De La Riva, K. M. Kendrick, Julietta Uta Frey, J. Bergado

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Long-term potentiation (LTP) is considered a cellular correlate of memory processing. A short-lasting early-LTP can be prolonged into a late-L TP (>4 h) by stimulation of the basolateral amygdala (BLA) or motivational behavioral stimuli in young, but not in aged, cognitively impaired rats. We measured the changes in transmitter release-induced by BLA or behavioral reinforcement-in young and aged cognitively impaired rats, after implanting a microdialysis cannula at the dentate gyrus. Samples were taken under baseline conditions and during stimulation of BLA. Rats were water deprived and tested again next day, taking samples after allowing access to water. Higher concentrations of choline, HIAA, aspartate, glutamate, and glycine were found in baseline samples from young animals compared to aged. In young animals, BLA stimulation increased the levels of ACh and reduced norepinephrine and serotonine, while behavioral reinforcement reduced the levels of glutamate and glycine. These effects were absent among aged rats, suggesting that this reduced neurochemical response might be linked to the impaired LTP-reinforcement reported previously.

Original languageEnglish (US)
Pages (from-to)877-883
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume327
Issue number3
DOIs
StatePublished - Feb 18 2005

Fingerprint

Long-Term Potentiation
Dentate Gyrus
Neurotransmitter Agents
Rats
Reinforcement
Glycine
Glutamic Acid
Animals
Water
Microdialysis
Choline
Aspartic Acid
Transmitters
Norepinephrine
Data storage equipment
Basolateral Nuclear Complex
Processing
Reinforcement (Psychology)

Keywords

  • Amygdala
  • Behavioral reinforcement
  • LTP
  • Microdialysis
  • Neurotransmitters

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Effect of LTP-reinforcing paradigms on neurotransmitter release in the dentate gyrus of young and aged rats. / Almaguer-Melian, W.; Cruz-Aguado, R.; Riva, C. De La; Kendrick, K. M.; Frey, Julietta Uta; Bergado, J.

In: Biochemical and Biophysical Research Communications, Vol. 327, No. 3, 18.02.2005, p. 877-883.

Research output: Contribution to journalArticle

Almaguer-Melian, W. ; Cruz-Aguado, R. ; Riva, C. De La ; Kendrick, K. M. ; Frey, Julietta Uta ; Bergado, J. / Effect of LTP-reinforcing paradigms on neurotransmitter release in the dentate gyrus of young and aged rats. In: Biochemical and Biophysical Research Communications. 2005 ; Vol. 327, No. 3. pp. 877-883.
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