Effect of molecular size on permeability coefficients in human dentine

David Henry Pashley, M. J. Livingston

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

The effect of increasing molecular radius on the rate of permeation of human dentine discs was determined. The substances tested were water, urea, fluoride, lidocaine, glucose, sucrose, inulin, dextran, polyvinylpyrrolindone and albumin. A 19-fold increase in molecular radius from 1.9 Å (3H2O) to 37 Å (131I-albumin) resulted in a 100-fold decrease in permeability coefficients calculated by the Fick equation. Acid-etching the dentine produced a 4-fold increase in 3H2O permeability and a 9-fold increase in 131I-albumin permeability. Both fluoride and chlorhexidine permeabilities were much lower than expected for their molecular weight or size, suggesting that they are bound to dentine. It is concluded that dentine permeability is determined, in part, by the nature of the dentine surface.

Original languageEnglish (US)
Pages (from-to)391-395
Number of pages5
JournalArchives of Oral Biology
Volume23
Issue number5
DOIs
StatePublished - Jan 1 1978

Fingerprint

Dentin
Permeability
Albumins
Fluorides
Dentin Permeability
Chlorhexidine
Inulin
Lidocaine
Dextrans
Sucrose
Urea
Molecular Weight
Glucose
Acids
Water

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

Cite this

Effect of molecular size on permeability coefficients in human dentine. / Pashley, David Henry; Livingston, M. J.

In: Archives of Oral Biology, Vol. 23, No. 5, 01.01.1978, p. 391-395.

Research output: Contribution to journalArticle

Pashley, David Henry ; Livingston, M. J. / Effect of molecular size on permeability coefficients in human dentine. In: Archives of Oral Biology. 1978 ; Vol. 23, No. 5. pp. 391-395.
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