TY - JOUR
T1 - Effect of molecular size on permeability coefficients in human dentine
AU - Pashley, D. H.
AU - Livingston, M. J.
N1 - Funding Information:
Acknowledgements-Thisw ork was supportedb y Dental ResearchG rant No. DE-03780f rom the National Institute of Dental Research.R adiofluoride was supplied by the Georgia Institute of Technologyw ith the support of the ERDA Reactor Sharing Program, Contract B380.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1978
Y1 - 1978
N2 - The effect of increasing molecular radius on the rate of permeation of human dentine discs was determined. The substances tested were water, urea, fluoride, lidocaine, glucose, sucrose, inulin, dextran, polyvinylpyrrolindone and albumin. A 19-fold increase in molecular radius from 1.9 Å (3H2O) to 37 Å (131I-albumin) resulted in a 100-fold decrease in permeability coefficients calculated by the Fick equation. Acid-etching the dentine produced a 4-fold increase in 3H2O permeability and a 9-fold increase in 131I-albumin permeability. Both fluoride and chlorhexidine permeabilities were much lower than expected for their molecular weight or size, suggesting that they are bound to dentine. It is concluded that dentine permeability is determined, in part, by the nature of the dentine surface.
AB - The effect of increasing molecular radius on the rate of permeation of human dentine discs was determined. The substances tested were water, urea, fluoride, lidocaine, glucose, sucrose, inulin, dextran, polyvinylpyrrolindone and albumin. A 19-fold increase in molecular radius from 1.9 Å (3H2O) to 37 Å (131I-albumin) resulted in a 100-fold decrease in permeability coefficients calculated by the Fick equation. Acid-etching the dentine produced a 4-fold increase in 3H2O permeability and a 9-fold increase in 131I-albumin permeability. Both fluoride and chlorhexidine permeabilities were much lower than expected for their molecular weight or size, suggesting that they are bound to dentine. It is concluded that dentine permeability is determined, in part, by the nature of the dentine surface.
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U2 - 10.1016/0003-9969(78)90098-5
DO - 10.1016/0003-9969(78)90098-5
M3 - Article
C2 - 278577
AN - SCOPUS:0017844136
SN - 0003-9969
VL - 23
SP - 391
EP - 395
JO - Archives of Oral Biology
JF - Archives of Oral Biology
IS - 5
ER -