Effects of acute volume loading and hemorrhage on intestinal vascular capacitance: A mechanism whereby capacitance modulates cardiac output

Nairne W. Scott-Douglas, Vincent J.B. Robinson, Otto A. Smiseth, Christopher I. Wright, Dante E. Manyari, Eldon R. Smith, John V. Tyberg

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background: Changes in intestinal vascular capacitance during acute volume loading and hemorrhage have not been described. Objectives: To determine the effects of volume loading and hemorrhage on the intestinal vascular pressure-volume relationship and cardiac output. Patients and methods: In 11 alpha-chloralose-anesthetized dogs, a pneumatic portal venous constrictor and catheter were positioned to increase and measure portal venous pressure (Ppv), respectively. Relative changes in intestinal blood volume (IBV) were determined by blood-pool scintigraphy and expressed as the percentage change from control values (taken as 100%). Ppv-IBV relationships were constructed by graded portal vein constriction. Results: IBV and cardiac output increased by 60±6% and 178±48%, respectively, and Ppv increased from 5.8±0.9 mmHg to 13.2±1.8 mmHg after initial volume loading (40 mL/kg of an isotonic glucose-saline solution over 7 min). IBV gradually decreased and reached near-control values after 75 min. In seven dogs, hemorrhage (sufficient to decrease mean aortic pressure by 56±4%) decreased IBV and cardiac output to 88±4% and 52±3% of control values, respectively, and Ppv decreased to 3.2±0.8 mmHg. Conclusions: A sigmoid function curve defined the relationship between cardiac output and IBV. Cardiac output remained constant over a wide range (between approximately 95% and 135% of control IBV). Outside this range, insufficient dilation or constriction resulted in a marked increase or decrease in venous pressures and cardiac output. These data indicate that vasculature capacitance modulates cardiac output during acute volume loading and hemorrhage, thereby maintaining cardiac output relatively constant over a wide range of total vascular blood volume.

Original languageEnglish (US)
Pages (from-to)515-522
Number of pages8
JournalCanadian Journal of Cardiology
Volume18
Issue number5
StatePublished - Jul 30 2002
Externally publishedYes

Keywords

  • Capacitance
  • Cardiac output
  • Circulation
  • Hemodynamics
  • Veins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Scott-Douglas, N. W., Robinson, V. J. B., Smiseth, O. A., Wright, C. I., Manyari, D. E., Smith, E. R., & Tyberg, J. V. (2002). Effects of acute volume loading and hemorrhage on intestinal vascular capacitance: A mechanism whereby capacitance modulates cardiac output. Canadian Journal of Cardiology, 18(5), 515-522.