Effects of estrogen, catechol estrogen metabolites, and tail-pinch on the firing rate of rat nigral dopamine neurons

J. K. Nishita, William Vaughn McCall, T. S. McDowell, M. A. Fichett, M. C. Kasper, E. H. Ellinwood

Research output: Contribution to journalArticle

Abstract

The effects of estradiol, 2-hydroxyestrone (2-OH-E1) and tail-pinch (TP) on dopamine (DA) neuron firing rates in the substantia nigra compacta (SNC) were examined. 17-beta-estradiol, 2-OH-El, and TP stimuli produced rapid changes in DA-cell firing rates whereas 17-alpha-estradiol and clomiphene had little effect. Our data demonstrate that 2-OH-El can produce similar changes in the SNC DA-cell activity as estrogen and that TP stimuli produce reliable changes in DA-cell firing rates that are dissociated from those induced by intravenous estrogen.

Original languageEnglish (US)
Pages (from-to)313-316
Number of pages4
JournalResearch Communications in Psychology, Psychiatry and Behavior
Volume13
Issue number4
StatePublished - Jan 1 1988
Externally publishedYes

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ASJC Scopus subject areas

  • Psychiatry and Mental health

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