The effects of estradiol, 2-hydroxyestrone (2-OH-E1) and tail-pinch (TP) on dopamine (DA) neuron firing rates in the substantia nigra compacta (SNC) were examined. 17-beta-estradiol, 2-OH-El, and TP stimuli produced rapid changes in DA-cell firing rates whereas 17-alpha-estradiol and clomiphene had little effect. Our data demonstrate that 2-OH-El can produce similar changes in the SNC DA-cell activity as estrogen and that TP stimuli produce reliable changes in DA-cell firing rates that are dissociated from those induced by intravenous estrogen.
|Original language||English (US)|
|Number of pages||4|
|Journal||Research Communications in Psychology, Psychiatry and Behavior|
|State||Published - Jan 1 1988|
ASJC Scopus subject areas
- Psychiatry and Mental health