Effects of motilin and octapeptide of cholecystokinin on antral and duodenal myoelectric activity in the interdigestive state and during inhibition by secretin and gastric inhibitory polypeptide

Manuel R Castresana, K. Y. Lee, W. Y. Chey, H. Yajima

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

In conscious dogs prepared with gastric cannulae and antral and duodenal electrodes, intravenous administration of synthetic porcine motilin and CCK-OP in varying doses resulted in significant increases in the mean percent frequency of spike potentials on slow waves. Motilin was a more potent stimulant than CCK-OP. Motilin-stimulated spike potentials in both antrum and duodenum were significantly suppressed by either natural porcine secretin or synthetic porcine GIP. Secretin suppressed the spike potentials of the antrum stimulated by CCK-OP but not those of the duodenum. The spike potentials stimulated by CCK-OP could not be suppressed by GIP in the dosages employed.

Original languageEnglish (US)
Pages (from-to)300-308
Number of pages9
JournalDigestion
Volume17
Issue number4
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

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Keywords

  • Antrum
  • CCK
  • Dogs
  • Duodenum
  • Gastrointestinal motility
  • GIP
  • Motilin
  • Myoelectric activity

ASJC Scopus subject areas

  • Gastroenterology

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