Effects of motilin and octapeptide of cholecystokinin on antral and duodenal myoelectric activity in the interdigestive state and during inhibition by secretin and gastric inhibitory polypeptide

Manuel R Castresana, K. Y. Lee, W. Y. Chey, H. Yajima

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In conscious dogs prepared with gastric cannulae and antral and duodenal electrodes, intravenous administration of synthetic porcine motilin and CCK-OP in varying doses resulted in significant increases in the mean percent frequency of spike potentials on slow waves. Motilin was a more potent stimulant than CCK-OP. Motilin-stimulated spike potentials in both antrum and duodenum were significantly suppressed by either natural porcine secretin or synthetic porcine GIP. Secretin suppressed the spike potentials of the antrum stimulated by CCK-OP but not those of the duodenum. The spike potentials stimulated by CCK-OP could not be suppressed by GIP in the dosages employed.

Original languageEnglish (US)
Pages (from-to)300-308
Number of pages9
JournalDigestion
Volume17
Issue number4
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

Fingerprint

Gastric Inhibitory Polypeptide
Motilin
Sincalide
Secretin
Action Potentials
Swine
Duodenum
Intravenous Administration
Stomach
Electrodes
Dogs
Antral

Keywords

  • Antrum
  • CCK
  • Dogs
  • Duodenum
  • Gastrointestinal motility
  • GIP
  • Motilin
  • Myoelectric activity

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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title = "Effects of motilin and octapeptide of cholecystokinin on antral and duodenal myoelectric activity in the interdigestive state and during inhibition by secretin and gastric inhibitory polypeptide",
abstract = "In conscious dogs prepared with gastric cannulae and antral and duodenal electrodes, intravenous administration of synthetic porcine motilin and CCK-OP in varying doses resulted in significant increases in the mean percent frequency of spike potentials on slow waves. Motilin was a more potent stimulant than CCK-OP. Motilin-stimulated spike potentials in both antrum and duodenum were significantly suppressed by either natural porcine secretin or synthetic porcine GIP. Secretin suppressed the spike potentials of the antrum stimulated by CCK-OP but not those of the duodenum. The spike potentials stimulated by CCK-OP could not be suppressed by GIP in the dosages employed.",
keywords = "Antrum, CCK, Dogs, Duodenum, Gastrointestinal motility, GIP, Motilin, Myoelectric activity",
author = "Castresana, {Manuel R} and Lee, {K. Y.} and Chey, {W. Y.} and H. Yajima",
year = "1978",
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language = "English (US)",
volume = "17",
pages = "300--308",
journal = "Digestion",
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publisher = "S. Karger AG",
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TY - JOUR

T1 - Effects of motilin and octapeptide of cholecystokinin on antral and duodenal myoelectric activity in the interdigestive state and during inhibition by secretin and gastric inhibitory polypeptide

AU - Castresana, Manuel R

AU - Lee, K. Y.

AU - Chey, W. Y.

AU - Yajima, H.

PY - 1978/1/1

Y1 - 1978/1/1

N2 - In conscious dogs prepared with gastric cannulae and antral and duodenal electrodes, intravenous administration of synthetic porcine motilin and CCK-OP in varying doses resulted in significant increases in the mean percent frequency of spike potentials on slow waves. Motilin was a more potent stimulant than CCK-OP. Motilin-stimulated spike potentials in both antrum and duodenum were significantly suppressed by either natural porcine secretin or synthetic porcine GIP. Secretin suppressed the spike potentials of the antrum stimulated by CCK-OP but not those of the duodenum. The spike potentials stimulated by CCK-OP could not be suppressed by GIP in the dosages employed.

AB - In conscious dogs prepared with gastric cannulae and antral and duodenal electrodes, intravenous administration of synthetic porcine motilin and CCK-OP in varying doses resulted in significant increases in the mean percent frequency of spike potentials on slow waves. Motilin was a more potent stimulant than CCK-OP. Motilin-stimulated spike potentials in both antrum and duodenum were significantly suppressed by either natural porcine secretin or synthetic porcine GIP. Secretin suppressed the spike potentials of the antrum stimulated by CCK-OP but not those of the duodenum. The spike potentials stimulated by CCK-OP could not be suppressed by GIP in the dosages employed.

KW - Antrum

KW - CCK

KW - Dogs

KW - Duodenum

KW - Gastrointestinal motility

KW - GIP

KW - Motilin

KW - Myoelectric activity

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