Effects of Multiple Sequential Extracorporeal Shock Wave Treatments on Renal Function: A Primate Model

Durwood E. Neal, Edwin Harmon, Timothy Hlavinka, Anne Morvant, Elizabeth Richardson, Raju Thomas

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

As extracorporeal shock wave lithotripsy (SWL) has been used for stones of increasing size, there has emerged a need for multiple treatments to fragment the stone adequately, and there has been some concern about the effect of these sequential treatments on renal function. No long-term studies are available as to the timing of a second or third treatment, nor of the effects on the individual kidney. We used six adult Rhesus monkeys (Macaca mulatta). The first group (N = 3) was treated with 2500 shocks at 28 kV to one kidney and the next group (N = 3) was treated with 2000 shocks at 18 kV at weekly intervals for 3 weeks. The animals were followed with quantitative renal camera studies prior to treatment, 48 hours after treatment, then weekly for 3 weeks, at 3 months, and at 6 months. The animals in the single-treatment group had a change in effective renal plasma flow (ERPF) of 2 ml/min per m2, which was equal to baseline (P > 0.1). In the multiple treatment group, there was a slight rise of ERPF (1 ml/min per m2) which was likewise equal to baseline (P > 0.1). Comparing the two groups, the ERPF data were equivalent. Urinary lactic dehydrogenase was elevated immediately after treatment, indicating some degree of tissue trauma, and returned to baseline by 3 weeks. One animal in the single-treatment group died from renal hemorrhage the day after treatment. Multiple SWL treatments spaced approximately 1 week apart have no apparent untoward effect on renal function compared with single high-dose treatment.

Original languageEnglish (US)
Pages (from-to)217-221
Number of pages5
JournalJournal of Endourology
Volume5
Issue number3
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Urology

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