Effects of scopolamine on visual evoked potentials in aging and dementia

P. G. Ray, K. J. Meador, D. W. Loring, A. M. Murro, J. J. Buccafusco, X. H. Yang, E. Y. Zamrini, W. O. Thompson, E. E. Thompson

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The unusual combination of a normal pattern reversal VEP and a delayed flash VEP has been reported in patients with dementia of Alzheimer's type (DAT). Hyoscine hydrobromide has been reported to produce a similar VEP abnormality in young, healthy subjects. In the present study, we assessed the relative sensitivity of DAT patients and healthy young, middle-aged and elderly subjects to temporary cholinergic blockade. We report VEP latency values following 3 doses of scopolamine and after a peripheral anticholinergic agent. Falsh P2 latency was not significantly slower in DAT patients than in the healthy elderly. Scopolamine increased P2 latency in the young controls but did not affect any other group. The pattern reversal P100 was normal in DAT, and a significant increase in latency occurred following scopolamine administration in both the control and patient groups.

Original languageEnglish (US)
Pages (from-to)347-351
Number of pages5
JournalElectroencephalography and Clinical Neurophysiology/ Evoked Potentials
Issue number5
StatePublished - 1991


  • Aging
  • Cholinergic blockade
  • Dementia
  • Scopolamine
  • Visual evoked potential

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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