Effects of serotonin antagonists on blood pressure in mineralocorticoid hypertensive sheep

T. E. Mecca, J. Mitchell, D. F. Bohr, R Clinton Webb

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The serotonin antagonist methysergide has a partial agonistic action on isolated vascular smooth muscle from hypertensive animais, whereas ketanserin, another serotonin antagonist, does not. The goal of this study was to determine the effects of these two agents on blood pressure in the conscious, deoxycorticosterone acetate (DOCA) hypertensive sheep. Adult sheep maintained on a standard laboratory diet and 0.1% NaCl/0.25% KCl drinking water developed hypertension fol-lowing DOCA implantation (mean arterial pressure: control = 83 mm Hg, DOCA = 108 mm Hg). Methysergide (40 μg/kg-i.v. bolus) produced a greater pressor response in hypertensive sheep than in normotensive sheep (control = 8 ± 1 mm Hg, DOCA = 18 ± 3 mm Hg). Ketanserin (50 μg/kg-i.v. bolus), on the other hand, caused a similar decrease in blood pressure (∼-16 mm Hg) in both control and DOCA sheep. Pressor responses to infusions of serotonin were greater in DOCA sheep compared with controls. Both methysergide and ketanserin were equally effective antagonists of a serotonin-induced pressor response (75% inhibition) in control and DOCA sheep. Methysergide had no effect on a norepinephrine-induced pressor response, but ketanserin caused a 20% attenuation of this response. These results demonstrate an enhanced responsiveness to serotonin and methysergide in DOCA hypertensive sheep.

Original languageEnglish (US)
Pages (from-to)660-665
Number of pages6
JournalJournal of Cardiovascular Pharmacology
Volume7
Issue number4
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Desoxycorticosterone
Mineralocorticoids
Serotonin Antagonists
Sheep
Acetates
Methysergide
Blood Pressure
Ketanserin
Serotonin
Vascular Smooth Muscle
Drinking Water
Norepinephrine
Arterial Pressure
Diet
Hypertension

Keywords

  • Deoxycorticosterone acetate
  • Ketanserin
  • Methysergide
  • Norepinephrine

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Effects of serotonin antagonists on blood pressure in mineralocorticoid hypertensive sheep. / Mecca, T. E.; Mitchell, J.; Bohr, D. F.; Webb, R Clinton.

In: Journal of Cardiovascular Pharmacology, Vol. 7, No. 4, 01.01.1985, p. 660-665.

Research output: Contribution to journalArticle

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