Effects of sodium pentothal and sufentanil on serotonin induced constriction of canine coronary artery rings without endothelium

R. P.S. Introna, J. K. Pruett, Dan C Martin, D. Josephson, M. Manabe

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Abstract

1. 1. The individual and combined effects of sufentanil and sodium pentothal on canine coronary artery vasomotor responses to 5-HT were studied in an isolated vascular ring preparation. 2. 2. Clinical concentrations of sufentanil have little effect on basal coronary tension or constriction induced by either 5-HT or sodium pentothal individually, until very high doses > 0.26 μM are reached. 3. 3. Sodium pentothal causes coronary constriction at clinical concentrations and this effect is additive and possibly potentiated when combined with 5-HT. 4. 4. Sufentanil inhibits coronary constriction induced by the combination of sodium pentothal and 5-HT.

Original languageEnglish (US)
Pages (from-to)589-594
Number of pages6
JournalGeneral Pharmacology
Volume22
Issue number4
DOIs
StatePublished - Jan 1 1991

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ASJC Scopus subject areas

  • Pharmacology

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