1. 1. The individual and combined effects of sufentanil and sodium pentothal on canine coronary artery vasomotor responses to 5-HT were studied in an isolated vascular ring preparation. 2. 2. Clinical concentrations of sufentanil have little effect on basal coronary tension or constriction induced by either 5-HT or sodium pentothal individually, until very high doses > 0.26 μM are reached. 3. 3. Sodium pentothal causes coronary constriction at clinical concentrations and this effect is additive and possibly potentiated when combined with 5-HT. 4. 4. Sufentanil inhibits coronary constriction induced by the combination of sodium pentothal and 5-HT.
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