Emerging molecular targets for treatment of erectile dysfunction

Vascular and regenerative therapies on the horizon

Inger Stallmann-Jorgensen, R Clinton Webb

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: Erectile dysfunction (ED) has reached epidemic proportions not expected to abate because of population aging and chronic diseases that accompany advanced age. Vasculopathy is a main cause, but damage to penile innervation also underlies many cases of ED. Phosphodiesterase inhibitor therapies do not help all men with ED, making the search for novel therapeutic drug and treatment targets of utmost importance. Aims: To review the literature to identify potential new treatment targets to fill a gap in therapeutic options for men with ED, with a focus on treatments for vasculogenic ED, but including novel treatment targets for ED due to penile nerve damage, a frequent consequence of pelvic surgery in men. Methods: The recent literature was searched for publications on in vitro, in vivo, pre-clinical and observational human studies, when available, that would identify potential new targets for ED therapies not previously, or not extensively reviewed. Results: Literature searches identified microparticles, myeloperoxidase, and heme oxygenase-1 as emerging molecular targets to treat vasculogenic ED. Novel regenerative therapy targets, including sonic hedgehog, galanin, and cell-based treatments were also reviewed as potential future treatments for ED due to damage to penile innervation. Conclusion: Novel molecular targets and cell-based therapies offer great hope for advances in ED treatment. Concerns regarding efficacy, toxicity, off target effects, safety, and convenience apply to these targets; much work remains to confirm these as viable targets to pursue for effective ED treatments. To complement targets discussed in this review relevant review papers were cited for the interested reader.

Original languageEnglish (US)
Pages (from-to)427-441
Number of pages15
JournalCurrent Drug Targets
Volume16
Issue number5
StatePublished - May 1 2015

Fingerprint

Erectile Dysfunction
Blood Vessels
Galanin
Heme Oxygenase-1
Phosphodiesterase Inhibitors
Surgery
Peroxidase
Toxicity
Therapeutics
Aging of materials
Pharmaceutical Preparations
Cell- and Tissue-Based Therapy
Observational Studies
Publications
Chronic Disease

Keywords

  • Erectile dysfunction
  • Heme oxygenase-1
  • Microparticles
  • Myeloperoxidase
  • Platelets
  • Regenerative therapies
  • Vascular inflammation

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Emerging molecular targets for treatment of erectile dysfunction : Vascular and regenerative therapies on the horizon. / Stallmann-Jorgensen, Inger; Webb, R Clinton.

In: Current Drug Targets, Vol. 16, No. 5, 01.05.2015, p. 427-441.

Research output: Contribution to journalArticle

@article{71ce1fae6d854ba18b8cfb196c1c27ce,
title = "Emerging molecular targets for treatment of erectile dysfunction: Vascular and regenerative therapies on the horizon",
abstract = "Introduction: Erectile dysfunction (ED) has reached epidemic proportions not expected to abate because of population aging and chronic diseases that accompany advanced age. Vasculopathy is a main cause, but damage to penile innervation also underlies many cases of ED. Phosphodiesterase inhibitor therapies do not help all men with ED, making the search for novel therapeutic drug and treatment targets of utmost importance. Aims: To review the literature to identify potential new treatment targets to fill a gap in therapeutic options for men with ED, with a focus on treatments for vasculogenic ED, but including novel treatment targets for ED due to penile nerve damage, a frequent consequence of pelvic surgery in men. Methods: The recent literature was searched for publications on in vitro, in vivo, pre-clinical and observational human studies, when available, that would identify potential new targets for ED therapies not previously, or not extensively reviewed. Results: Literature searches identified microparticles, myeloperoxidase, and heme oxygenase-1 as emerging molecular targets to treat vasculogenic ED. Novel regenerative therapy targets, including sonic hedgehog, galanin, and cell-based treatments were also reviewed as potential future treatments for ED due to damage to penile innervation. Conclusion: Novel molecular targets and cell-based therapies offer great hope for advances in ED treatment. Concerns regarding efficacy, toxicity, off target effects, safety, and convenience apply to these targets; much work remains to confirm these as viable targets to pursue for effective ED treatments. To complement targets discussed in this review relevant review papers were cited for the interested reader.",
keywords = "Erectile dysfunction, Heme oxygenase-1, Microparticles, Myeloperoxidase, Platelets, Regenerative therapies, Vascular inflammation",
author = "Inger Stallmann-Jorgensen and Webb, {R Clinton}",
year = "2015",
month = "5",
day = "1",
language = "English (US)",
volume = "16",
pages = "427--441",
journal = "Current Drug Targets",
issn = "1389-4501",
publisher = "Bentham Science Publishers B.V.",
number = "5",

}

TY - JOUR

T1 - Emerging molecular targets for treatment of erectile dysfunction

T2 - Vascular and regenerative therapies on the horizon

AU - Stallmann-Jorgensen, Inger

AU - Webb, R Clinton

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Introduction: Erectile dysfunction (ED) has reached epidemic proportions not expected to abate because of population aging and chronic diseases that accompany advanced age. Vasculopathy is a main cause, but damage to penile innervation also underlies many cases of ED. Phosphodiesterase inhibitor therapies do not help all men with ED, making the search for novel therapeutic drug and treatment targets of utmost importance. Aims: To review the literature to identify potential new treatment targets to fill a gap in therapeutic options for men with ED, with a focus on treatments for vasculogenic ED, but including novel treatment targets for ED due to penile nerve damage, a frequent consequence of pelvic surgery in men. Methods: The recent literature was searched for publications on in vitro, in vivo, pre-clinical and observational human studies, when available, that would identify potential new targets for ED therapies not previously, or not extensively reviewed. Results: Literature searches identified microparticles, myeloperoxidase, and heme oxygenase-1 as emerging molecular targets to treat vasculogenic ED. Novel regenerative therapy targets, including sonic hedgehog, galanin, and cell-based treatments were also reviewed as potential future treatments for ED due to damage to penile innervation. Conclusion: Novel molecular targets and cell-based therapies offer great hope for advances in ED treatment. Concerns regarding efficacy, toxicity, off target effects, safety, and convenience apply to these targets; much work remains to confirm these as viable targets to pursue for effective ED treatments. To complement targets discussed in this review relevant review papers were cited for the interested reader.

AB - Introduction: Erectile dysfunction (ED) has reached epidemic proportions not expected to abate because of population aging and chronic diseases that accompany advanced age. Vasculopathy is a main cause, but damage to penile innervation also underlies many cases of ED. Phosphodiesterase inhibitor therapies do not help all men with ED, making the search for novel therapeutic drug and treatment targets of utmost importance. Aims: To review the literature to identify potential new treatment targets to fill a gap in therapeutic options for men with ED, with a focus on treatments for vasculogenic ED, but including novel treatment targets for ED due to penile nerve damage, a frequent consequence of pelvic surgery in men. Methods: The recent literature was searched for publications on in vitro, in vivo, pre-clinical and observational human studies, when available, that would identify potential new targets for ED therapies not previously, or not extensively reviewed. Results: Literature searches identified microparticles, myeloperoxidase, and heme oxygenase-1 as emerging molecular targets to treat vasculogenic ED. Novel regenerative therapy targets, including sonic hedgehog, galanin, and cell-based treatments were also reviewed as potential future treatments for ED due to damage to penile innervation. Conclusion: Novel molecular targets and cell-based therapies offer great hope for advances in ED treatment. Concerns regarding efficacy, toxicity, off target effects, safety, and convenience apply to these targets; much work remains to confirm these as viable targets to pursue for effective ED treatments. To complement targets discussed in this review relevant review papers were cited for the interested reader.

KW - Erectile dysfunction

KW - Heme oxygenase-1

KW - Microparticles

KW - Myeloperoxidase

KW - Platelets

KW - Regenerative therapies

KW - Vascular inflammation

UR - http://www.scopus.com/inward/record.url?scp=84929665214&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929665214&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 427

EP - 441

JO - Current Drug Targets

JF - Current Drug Targets

SN - 1389-4501

IS - 5

ER -