Endocrine-autonomic linkages

Celia D. Sladek, Lisete C. Michelini, Nina S. Stachenfeld, Javier Eduardo Stern, Janice H. Urban

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Interaction between the autonomic nervous system and the neuroendocrine system is critical for maintenance of homeostasis in a wide variety of physiological parameters such as body temperature, fluid and electrolyte balance, and blood pressure and volume. The anatomical and physiological mechanisms underlying integration of the neuroendocrine and autonomic mechanisms responsible for eliciting integrated autonomic and neuroendocrine actions are the focus of this article. This includes a focus on the hypothalamic paraventricular nucleus, because it includes both neuroendocrine neurons and preganglionic autonomic neurons that regulate sympathetic and parasympathetic outflow. The "wired" and "nonwired" mechanisms within PVN that facilitate communication between these neuronal populations are described. The impact of peripheral hormones, specifically the adrenal and gonadal steroids, on the neuroendocrine and autonomic systems is discussed, and exercise is used as a specific example of a physiological challenge/stress that requires precise integration of neuroendocrine and autonomic responses to maintain cardiovascular, fluid, and energy homeostasis.

Original languageEnglish (US)
Pages (from-to)1281-1323
Number of pages43
JournalComprehensive Physiology
Volume5
Issue number3
DOIs
StatePublished - Jul 1 2015

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Neurosecretory Systems
Water-Electrolyte Balance
Homeostasis
Neurons
Paraventricular Hypothalamic Nucleus
Autonomic Nervous System
Body Fluids
Blood Volume
Body Temperature
Steroids
Maintenance
Hormones
Blood Pressure
Population

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Sladek, C. D., Michelini, L. C., Stachenfeld, N. S., Stern, J. E., & Urban, J. H. (2015). Endocrine-autonomic linkages. Comprehensive Physiology, 5(3), 1281-1323. https://doi.org/10.1002/cphy.c140028

Endocrine-autonomic linkages. / Sladek, Celia D.; Michelini, Lisete C.; Stachenfeld, Nina S.; Stern, Javier Eduardo; Urban, Janice H.

In: Comprehensive Physiology, Vol. 5, No. 3, 01.07.2015, p. 1281-1323.

Research output: Contribution to journalArticle

Sladek, CD, Michelini, LC, Stachenfeld, NS, Stern, JE & Urban, JH 2015, 'Endocrine-autonomic linkages', Comprehensive Physiology, vol. 5, no. 3, pp. 1281-1323. https://doi.org/10.1002/cphy.c140028
Sladek CD, Michelini LC, Stachenfeld NS, Stern JE, Urban JH. Endocrine-autonomic linkages. Comprehensive Physiology. 2015 Jul 1;5(3):1281-1323. https://doi.org/10.1002/cphy.c140028
Sladek, Celia D. ; Michelini, Lisete C. ; Stachenfeld, Nina S. ; Stern, Javier Eduardo ; Urban, Janice H. / Endocrine-autonomic linkages. In: Comprehensive Physiology. 2015 ; Vol. 5, No. 3. pp. 1281-1323.
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