TY - JOUR
T1 - Endocrine profile of follicles containing oocytes with subsequent polyploid fertilization
AU - Webster, B. W.
AU - Diamond, M. P.
AU - Osteen, K. G.
AU - Wentz, A. C.
PY - 1988
Y1 - 1988
N2 - In an attempt to identify oocytes at risk for polypronuclear fertilization, follicular fluids were obtained retrospectively that contained oocytes that fertilized normally and abnormally. Whenever possible, each patient served as her own control during the same stimulation cycle. Twenty-six of 169 patients had oocytes that became polypronuclear, and of those 26, 21 had oocytes that fertilized and cleaved normally. Follicular fluids were analyzed for estradiol, progesterone, androstenedione, transferrin, and insulin. Insulin levels were noted to be significantly elevated (P < 0.05) in the polypronuclear group when compropose that insulin, a known growth factor for granulosa cells cultured in vitro, when present in excessive concentrations may predispose to polypronuclear fertilization.
AB - In an attempt to identify oocytes at risk for polypronuclear fertilization, follicular fluids were obtained retrospectively that contained oocytes that fertilized normally and abnormally. Whenever possible, each patient served as her own control during the same stimulation cycle. Twenty-six of 169 patients had oocytes that became polypronuclear, and of those 26, 21 had oocytes that fertilized and cleaved normally. Follicular fluids were analyzed for estradiol, progesterone, androstenedione, transferrin, and insulin. Insulin levels were noted to be significantly elevated (P < 0.05) in the polypronuclear group when compropose that insulin, a known growth factor for granulosa cells cultured in vitro, when present in excessive concentrations may predispose to polypronuclear fertilization.
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U2 - 10.1016/S0015-0282(16)60306-0
DO - 10.1016/S0015-0282(16)60306-0
M3 - Article
C2 - 3053255
AN - SCOPUS:0023685054
SN - 0015-0282
VL - 50
SP - 727
EP - 731
JO - Fertility and sterility
JF - Fertility and sterility
IS - 5
ER -