Endogenous pyrogen activity in human plasma after exercise

Joseph G. Cannon, Matthew J. Kluger

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Plasma obtained from human subjects after exercise and injected intraperitoneally into rats elevated rat rectal temperature and depressed plasma iron and zinc concentrations. The pyrogenic component was heat-denaturable and had an apparent molecular weight of 14,000 daltons. Human mononuclear leukocytes obtained after exercise and incubated in vitro released a factor into the medium that also elevated body temperature in rats and reduced trace metal concentrations. These results suggest that endogenous pyrogen, a protein mediator of fever and trace metal metabolism during infection, is released during exercise.

Original languageEnglish (US)
Pages (from-to)617-619
Number of pages3
Issue number4597
Publication statusPublished - Jan 1 1983


ASJC Scopus subject areas

  • General

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