Endogenous pyrogen activity in human plasma after exercise

Joseph G. Cannon, Matthew J. Kluger

Research output: Contribution to journalArticle

185 Scopus citations

Abstract

Plasma obtained from human subjects after exercise and injected intraperitoneally into rats elevated rat rectal temperature and depressed plasma iron and zinc concentrations. The pyrogenic component was heat-denaturable and had an apparent molecular weight of 14,000 daltons. Human mononuclear leukocytes obtained after exercise and incubated in vitro released a factor into the medium that also elevated body temperature in rats and reduced trace metal concentrations. These results suggest that endogenous pyrogen, a protein mediator of fever and trace metal metabolism during infection, is released during exercise.

Original languageEnglish (US)
Pages (from-to)617-619
Number of pages3
JournalScience
Volume220
Issue number4597
DOIs
Publication statusPublished - Jan 1 1983

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