Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites.

Christoph Wiesner, Jiri Kopecky, Maren Pflueger, Harald Hundsberger, Barbara Entler, Christoph Kleber, Josef Atzler, Pavel Hrouzek, Dalibor Stys, Alena Lukesova, Wolfgang Schuett, Rudolf Lucas

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Acute lung injury is accompanied by an increased endothelial chemokine production and adhesion molecule expression, which may result in an extensive neutrophil infiltration. Moreover, a destruction of the alveolar epithelium and capillary endothelium may result in permeability edema. As such, the search for novel anti-inflammatory substances, able to downregulate these parameters as well as the tissue damage holds therapeutic promise. We therefore describe here the use of human endothelial cell-based in vitro assays for the detection of anti-inflammatory and wound-healing metabolites from cyanobacteria.

Original languageEnglish (US)
Pages (from-to)254-260
Number of pages7
JournalDrug Metabolism Letters
Volume1
Issue number4
DOIs
StatePublished - Jan 1 2007

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Endothelial cells
Metabolites
Wound Healing
Anti-Inflammatory Agents
Endothelial Cells
Neutrophil Infiltration
Acute Lung Injury
Vascular Endothelium
Cyanobacteria
Chemokines
Infiltration
Permeability
Assays
Edema
Down-Regulation
Adhesion
Epithelium
Tissue
Molecules
Therapeutics

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Clinical Biochemistry
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites. / Wiesner, Christoph; Kopecky, Jiri; Pflueger, Maren; Hundsberger, Harald; Entler, Barbara; Kleber, Christoph; Atzler, Josef; Hrouzek, Pavel; Stys, Dalibor; Lukesova, Alena; Schuett, Wolfgang; Lucas, Rudolf.

In: Drug Metabolism Letters, Vol. 1, No. 4, 01.01.2007, p. 254-260.

Research output: Contribution to journalArticle

Wiesner, C, Kopecky, J, Pflueger, M, Hundsberger, H, Entler, B, Kleber, C, Atzler, J, Hrouzek, P, Stys, D, Lukesova, A, Schuett, W & Lucas, R 2007, 'Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites.', Drug Metabolism Letters, vol. 1, no. 4, pp. 254-260. https://doi.org/10.2174/187231207783221385
Wiesner, Christoph ; Kopecky, Jiri ; Pflueger, Maren ; Hundsberger, Harald ; Entler, Barbara ; Kleber, Christoph ; Atzler, Josef ; Hrouzek, Pavel ; Stys, Dalibor ; Lukesova, Alena ; Schuett, Wolfgang ; Lucas, Rudolf. / Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites. In: Drug Metabolism Letters. 2007 ; Vol. 1, No. 4. pp. 254-260.
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