Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites.

Christoph Wiesner, Jiri Kopecky, Maren Pflueger, Harald Hundsberger, Barbara Entler, Christoph Kleber, Josef Atzler, Pavel Hrouzek, Dalibor Stys, Alena Lukesova, Wolfgang Schuett, Rudolf Lucas

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Acute lung injury is accompanied by an increased endothelial chemokine production and adhesion molecule expression, which may result in an extensive neutrophil infiltration. Moreover, a destruction of the alveolar epithelium and capillary endothelium may result in permeability edema. As such, the search for novel anti-inflammatory substances, able to downregulate these parameters as well as the tissue damage holds therapeutic promise. We therefore describe here the use of human endothelial cell-based in vitro assays for the detection of anti-inflammatory and wound-healing metabolites from cyanobacteria.

Original languageEnglish (US)
Pages (from-to)254-260
Number of pages7
JournalDrug Metabolism Letters
Volume1
Issue number4
DOIs
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Clinical Biochemistry
  • Biochemistry, medical
  • Pharmacology (medical)

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    Wiesner, C., Kopecky, J., Pflueger, M., Hundsberger, H., Entler, B., Kleber, C., Atzler, J., Hrouzek, P., Stys, D., Lukesova, A., Schuett, W., & Lucas, R. (2007). Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites. Drug Metabolism Letters, 1(4), 254-260. https://doi.org/10.2174/187231207783221385