Engineered Microneedle Patches for Controlled Release of Active Compounds: Recent Advances in Release Profile Tuning

Rezvan Jamaledin, Pooyan Makvandi, Cynthia K.Y. Yiu, Tarun Agarwal, Raffaele Vecchione, Wujin Sun, Tapas Kumar Maiti, Franklin R. Tay, Paolo Antonio Netti

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Transdermal microneedle patches have attracted significant attention in the medical arena over the last decade as alternatives to traditional drug delivery methods. Microneedle patches are capable of delivering their payloads using burst- and sustained-release mechanisms, or in response to internal/external triggers, to optimize their therapeutic potency. Herein, drug release mechanisms and profiles are reviewed, along with the impact of the cargo release on cytotoxicity and delivery efficacy. The potential applications of microneedles in transdermal treatment, from prophylaxis to therapeutics, are also highlighted.

Original languageEnglish (US)
Article number2000171
JournalAdvanced Therapeutics
Volume3
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • controlled release
  • drug delivery efficacy
  • drug release mechanisms
  • microneedles
  • responsive microneedles
  • transdermal patches

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Pharmaceutical Science
  • Genetics(clinical)
  • Biochemistry, medical
  • Pharmacology (medical)

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