Engineering α-fetoprotein-based gene vaccines to prevent and treat hepatocellular carcinoma: Review and future prospects

Yukai He, Yuan Hong, Gerald J. Mizejewski

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Activation of a patient's immune system offers an attractive approach to prevent and treat hepatocellular carcinoma (HCC). However, the antitumor efficacy of current HCC vaccines was weak owing to insufficient immune activation of targeting self/tumor antigens. We recently found that epitope-optimized α-fetoprotein effectively activated CD8 T cells and generated potent antitumor effects in the carcinogen-induced autochthonous HCC mouse model. We predict that the same antigen engineering approach of epitope-optimization will enable us to develop effective human vaccines to prevent HCC recurrence after liver resection. The engineered human HCC vaccines may also allow us to identify high-affinity T-cell receptors and antibodies that can be used to reprogram T cells to treat HCC tumors via adoptive transfer.

Original languageEnglish (US)
Pages (from-to)725-736
Number of pages12
JournalImmunotherapy
Volume6
Issue number6
DOIs
StatePublished - Jun 2014

Keywords

  • antigen engineering
  • cancer vaccine
  • epitope optimization
  • genetic immunization
  • hepatocellular carcinoma
  • immunotherapy
  • recombinant lentivector

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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