Enzymatic regulation and functional relevance of NOX5

Feng Chen, Yusi Wang, Scott Barman, David J.R. Fulton

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

The NADPH oxidases (NOX) represent a family of 7 related transmembrane enzymes that share a basic structural paradigm and the common ability to utilize NADPH to synthesize superoxide and other reactive oxygen species (ROS). NOX isoforms are distinguished from each other by their amino acid sequences, expression levels in different cell types, the mechanisms of enzyme activation and the type of ROS that are generated. NOX5 was the last NOX family member to be identified and in the past decade and a half we have gained significant insights into how NOX5 produces ROS, the cell types where it is expressed and the functional significance of NOX5 in health and disease. The objective of this review is to highlight accumulated and recent knowledge of the genetic and en- zymatic regulation of NOX5 and the importance of NOX5 in human physiology and pathophysiology.

Original languageEnglish (US)
Pages (from-to)5999-6008
Number of pages10
JournalCurrent Pharmaceutical Design
Volume21
Issue number41
DOIs
StatePublished - Jan 1 2015

Keywords

  • Genetic regulation
  • NADPH oxidase
  • NOX5
  • Post-translational regulation
  • Reactive oxygen species
  • Review
  • Significance

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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