Eosinophilic Pleural Effusion Due to Dantrolene: Resolution with Steroid Therapy

Michael W. Felz, Dolores J. Haviland-Foley

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Abstract

A quadriplegic patient with severe spasticity, treated with dantrolene (400 mg daily) for 5 years, had dyspnea, orthopnea, hypoxia, and right-sided opacity of the chest on radiograph. At thoracentesis, an exudative effusion containing 64% eosinophils was documented, with simultaneous peripheral eosinophilia of 11%. An allergic reaction to dantrolene was postulated. Despite withdrawal of the offending medication and repeated thoracenteses, symptomatic recurrence of effusion persisted for 4 days. After institution of prednisone therapy, rapid resolution of symptoms, signs, hypoxia, and radiologic abnormalities was observed. In contrast to five previously reported cases of dantrolene-associated eosinophilic pleural effusion (EPE), ours represents the first in which the patient was treated with steroids and suggests that steroid therapy may be of benefit in drug-related EPE.

Original languageEnglish (US)
Pages (from-to)502-504
Number of pages3
JournalSouthern Medical Journal
Volume94
Issue number5
StatePublished - May 1 2001

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ASJC Scopus subject areas

  • Medicine(all)

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