Eosinophilic Pleural Effusion Due to Dantrolene: Resolution with Steroid Therapy

Michael W. Felz, Dolores J. Haviland-Foley

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A quadriplegic patient with severe spasticity, treated with dantrolene (400 mg daily) for 5 years, had dyspnea, orthopnea, hypoxia, and right-sided opacity of the chest on radiograph. At thoracentesis, an exudative effusion containing 64% eosinophils was documented, with simultaneous peripheral eosinophilia of 11%. An allergic reaction to dantrolene was postulated. Despite withdrawal of the offending medication and repeated thoracenteses, symptomatic recurrence of effusion persisted for 4 days. After institution of prednisone therapy, rapid resolution of symptoms, signs, hypoxia, and radiologic abnormalities was observed. In contrast to five previously reported cases of dantrolene-associated eosinophilic pleural effusion (EPE), ours represents the first in which the patient was treated with steroids and suggests that steroid therapy may be of benefit in drug-related EPE.

Original languageEnglish (US)
Pages (from-to)502-504
Number of pages3
JournalSouthern Medical Journal
Volume94
Issue number5
StatePublished - May 1 2001

Fingerprint

Dantrolene
Pleural Effusion
Steroids
Eosinophilia
Prednisone
Eosinophils
Dyspnea
Signs and Symptoms
Hypersensitivity
Thorax
Therapeutics
Recurrence
Pharmaceutical Preparations
Thoracentesis
Hypoxia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Eosinophilic Pleural Effusion Due to Dantrolene : Resolution with Steroid Therapy. / Felz, Michael W.; Haviland-Foley, Dolores J.

In: Southern Medical Journal, Vol. 94, No. 5, 01.05.2001, p. 502-504.

Research output: Contribution to journalArticle

Felz, MW & Haviland-Foley, DJ 2001, 'Eosinophilic Pleural Effusion Due to Dantrolene: Resolution with Steroid Therapy', Southern Medical Journal, vol. 94, no. 5, pp. 502-504.
Felz, Michael W. ; Haviland-Foley, Dolores J. / Eosinophilic Pleural Effusion Due to Dantrolene : Resolution with Steroid Therapy. In: Southern Medical Journal. 2001 ; Vol. 94, No. 5. pp. 502-504.
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