TY - JOUR
T1 - Epigenetic Regulation in Kidney Toxicity
T2 - Insights From Cisplatin Nephrotoxicity
AU - Xiang, Xiaohong
AU - Guo, Chunyuan
AU - Tang, Chengyuan
AU - Cai, Juan
AU - Dong, Zheng
PY - 2019/3
Y1 - 2019/3
N2 - Summary: Nephrotoxicity, as a result of the exposure of kidney to endogenous and exogenous toxins, is an important factor for acute kidney injury and the development of progressive chronic kidney disease. Cisplatin is among the most widely studied kidney toxicants. In the past decade, epigenetic regulation has emerged as a notable pathogenic mechanism in cisplatin nephrotoxicity, including DNA methylation, histone modification, and noncoding RNAs. In this review, we use cisplatin nephrotoxicity as an example to highlight the epigenetic alteration, function, and underlying mechanism in kidney toxicity. The study of epigenetic regulation in kidney toxicity is still in its infancy, and further investigation will bring new insights for the development of novel diagnostic biomarkers and therapeutic interventions.
AB - Summary: Nephrotoxicity, as a result of the exposure of kidney to endogenous and exogenous toxins, is an important factor for acute kidney injury and the development of progressive chronic kidney disease. Cisplatin is among the most widely studied kidney toxicants. In the past decade, epigenetic regulation has emerged as a notable pathogenic mechanism in cisplatin nephrotoxicity, including DNA methylation, histone modification, and noncoding RNAs. In this review, we use cisplatin nephrotoxicity as an example to highlight the epigenetic alteration, function, and underlying mechanism in kidney toxicity. The study of epigenetic regulation in kidney toxicity is still in its infancy, and further investigation will bring new insights for the development of novel diagnostic biomarkers and therapeutic interventions.
KW - DNA methylation
KW - Epigenetic
KW - cisplatin nephrotoxicity
KW - histone modification
KW - noncoding RNAs
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U2 - 10.1016/j.semnephrol.2018.12.005
DO - 10.1016/j.semnephrol.2018.12.005
M3 - Review article
C2 - 30827338
AN - SCOPUS:85061663802
SN - 0270-9295
VL - 39
SP - 152
EP - 158
JO - Seminars in Nephrology
JF - Seminars in Nephrology
IS - 2
ER -