Epigenetics, stress, and depression

Laura Lockwood, Shaoyong Su, Nagy Adel Youssef

Research output: Chapter in Book/Report/Conference proceedingChapter


Epigenetics involves functional modifications of genes that are affected by environmental factors. The aim of this chapter is to explore if an association exists between epigenetics and depression in humans. Medline/PubMed searches were performed using Medical Subject Heading (MeSH) terms. Based on prespecified terms and inclusion criteria, 16 studies met inclusion criteria by 2 independent reviewers. Epigenetic changes seem to be important in depression. All of the studies reviewed herein found significant epigenetic changes associated with depression. Future research is needed in a larger sample to further characterize these changes.

Original languageEnglish (US)
Title of host publicationEpigenetics of Stress and Stress Disorders
Number of pages14
ISBN (Electronic)9780128230398
ISBN (Print)9780128230626
StatePublished - Jan 1 2022


  • Epigenomics
  • Frontal cortex
  • Genetic sequence
  • Peripheral blood
  • Postmortem brain tissue

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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