ErbB4 is a suppressor of long-term potentiation in the adult hippocampus

Graham M. Pitcher, Simon Beggs, Ran Sook Woo, Lin Mei, Michael W. Salter

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

ErbB4 has emerged as a leading susceptibility gene for schizophrenia but the function of the ErbB4 receptor in the adult brain is unknown. Here, we show in the adult hippocampus that long-term potentiation (LTP) of transmission at Schaffer collateral CA1 synapses was markedly enhanced in mutant mice lacking ErbB4. Concordantly, LTP was enhanced by acutely blocking ErbB4 in wild-type animals, indicating that ErbB4 activity constitutively suppresses LTP. Moreover, increasing ErbB4 signaling further suppressed LTP. By contrast, altering ErbB4 activity did not affect basal synaptic transmission or short-term facilitation. Our findings suggest that cognitive deficits in schizophrenia may be a consequence of hyperfunction of ErbB4 signaling leading to suppressed glutamatergic synaptic plasticity, thus opening new approaches for the treatment of this disorder.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalNeuroReport
Volume19
Issue number2
DOIs
StatePublished - Jan 1 2008

Fingerprint

Long-Term Potentiation
Hippocampus
Schizophrenia
Neuronal Plasticity
Wild Animals
Synaptic Transmission
Synapses
Brain
Genes

Keywords

  • ErbB4
  • Long-term potentiation
  • Neuregulin
  • Paired-pulse facilitation
  • Schaffer collateral CA1 synapses
  • Synaptic plasticity
  • Theta burst stimulation
  • Transgenic mouse

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Pitcher, G. M., Beggs, S., Woo, R. S., Mei, L., & Salter, M. W. (2008). ErbB4 is a suppressor of long-term potentiation in the adult hippocampus. NeuroReport, 19(2), 139-143. https://doi.org/10.1097/WNR.0b013e3282f3da10

ErbB4 is a suppressor of long-term potentiation in the adult hippocampus. / Pitcher, Graham M.; Beggs, Simon; Woo, Ran Sook; Mei, Lin; Salter, Michael W.

In: NeuroReport, Vol. 19, No. 2, 01.01.2008, p. 139-143.

Research output: Contribution to journalArticle

Pitcher, GM, Beggs, S, Woo, RS, Mei, L & Salter, MW 2008, 'ErbB4 is a suppressor of long-term potentiation in the adult hippocampus', NeuroReport, vol. 19, no. 2, pp. 139-143. https://doi.org/10.1097/WNR.0b013e3282f3da10
Pitcher, Graham M. ; Beggs, Simon ; Woo, Ran Sook ; Mei, Lin ; Salter, Michael W. / ErbB4 is a suppressor of long-term potentiation in the adult hippocampus. In: NeuroReport. 2008 ; Vol. 19, No. 2. pp. 139-143.
@article{af9ad420006c4d90a71d7725932e23f5,
title = "ErbB4 is a suppressor of long-term potentiation in the adult hippocampus",
abstract = "ErbB4 has emerged as a leading susceptibility gene for schizophrenia but the function of the ErbB4 receptor in the adult brain is unknown. Here, we show in the adult hippocampus that long-term potentiation (LTP) of transmission at Schaffer collateral CA1 synapses was markedly enhanced in mutant mice lacking ErbB4. Concordantly, LTP was enhanced by acutely blocking ErbB4 in wild-type animals, indicating that ErbB4 activity constitutively suppresses LTP. Moreover, increasing ErbB4 signaling further suppressed LTP. By contrast, altering ErbB4 activity did not affect basal synaptic transmission or short-term facilitation. Our findings suggest that cognitive deficits in schizophrenia may be a consequence of hyperfunction of ErbB4 signaling leading to suppressed glutamatergic synaptic plasticity, thus opening new approaches for the treatment of this disorder.",
keywords = "ErbB4, Long-term potentiation, Neuregulin, Paired-pulse facilitation, Schaffer collateral CA1 synapses, Synaptic plasticity, Theta burst stimulation, Transgenic mouse",
author = "Pitcher, {Graham M.} and Simon Beggs and Woo, {Ran Sook} and Lin Mei and Salter, {Michael W.}",
year = "2008",
month = "1",
day = "1",
doi = "10.1097/WNR.0b013e3282f3da10",
language = "English (US)",
volume = "19",
pages = "139--143",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - ErbB4 is a suppressor of long-term potentiation in the adult hippocampus

AU - Pitcher, Graham M.

AU - Beggs, Simon

AU - Woo, Ran Sook

AU - Mei, Lin

AU - Salter, Michael W.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - ErbB4 has emerged as a leading susceptibility gene for schizophrenia but the function of the ErbB4 receptor in the adult brain is unknown. Here, we show in the adult hippocampus that long-term potentiation (LTP) of transmission at Schaffer collateral CA1 synapses was markedly enhanced in mutant mice lacking ErbB4. Concordantly, LTP was enhanced by acutely blocking ErbB4 in wild-type animals, indicating that ErbB4 activity constitutively suppresses LTP. Moreover, increasing ErbB4 signaling further suppressed LTP. By contrast, altering ErbB4 activity did not affect basal synaptic transmission or short-term facilitation. Our findings suggest that cognitive deficits in schizophrenia may be a consequence of hyperfunction of ErbB4 signaling leading to suppressed glutamatergic synaptic plasticity, thus opening new approaches for the treatment of this disorder.

AB - ErbB4 has emerged as a leading susceptibility gene for schizophrenia but the function of the ErbB4 receptor in the adult brain is unknown. Here, we show in the adult hippocampus that long-term potentiation (LTP) of transmission at Schaffer collateral CA1 synapses was markedly enhanced in mutant mice lacking ErbB4. Concordantly, LTP was enhanced by acutely blocking ErbB4 in wild-type animals, indicating that ErbB4 activity constitutively suppresses LTP. Moreover, increasing ErbB4 signaling further suppressed LTP. By contrast, altering ErbB4 activity did not affect basal synaptic transmission or short-term facilitation. Our findings suggest that cognitive deficits in schizophrenia may be a consequence of hyperfunction of ErbB4 signaling leading to suppressed glutamatergic synaptic plasticity, thus opening new approaches for the treatment of this disorder.

KW - ErbB4

KW - Long-term potentiation

KW - Neuregulin

KW - Paired-pulse facilitation

KW - Schaffer collateral CA1 synapses

KW - Synaptic plasticity

KW - Theta burst stimulation

KW - Transgenic mouse

UR - http://www.scopus.com/inward/record.url?scp=38049158214&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38049158214&partnerID=8YFLogxK

U2 - 10.1097/WNR.0b013e3282f3da10

DO - 10.1097/WNR.0b013e3282f3da10

M3 - Article

VL - 19

SP - 139

EP - 143

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 2

ER -