The erythropoiesis inhibitory fraction (EIF) isolated from different plasmas is equally effective on a weight basis. However, the yield of the plasma EIF fraction varies relative to the source. In general, the amounts of the inhibitor fraction seem to increase with, but not parallel to, increased erythropoiesis. A young girl with recessive erythrocytosis, and a renal transplant patient, however, have a relative deficiency of the EIF fraction which could explain the erythrocytosis.
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