Ethanol wet-bonding challenges current anti-degradation strategy

F. T. Sadek, R. R. Braga, A. Muench, Y. Liu, David Henry Pashley, Franklin Chi Meng Tay

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

The long-term effectiveness of chlorhexidine as a matrix metalloproteinase (MMP) inhibitor may be compromised when water is incompletely removed during dentin bonding. This study challenged this anti-bond degradation strategy by testing the null hypothesis that wet-bonding with water or ethanol has no effect on the effectiveness of chlorhexidine in preventing hybrid layer degradation over an 18-month period. Acid-etched dentin was bonded under pulpal pressure simulation with Scotchbond MP and Single Bond 2, with water wet-bonding or with a hydrophobic adhesive with ethanol wet-bonding, with or without pre-treatment with chlorhexidine diacetate (CHD). Resin-dentin beams were prepared for bond strength and TEM evaluation after 24 hrs and after aging in artificial saliva for 9 and 18 mos. Bonds made to ethanol-saturated dentin did not change over time with preservation of hybrid layer integrity. Bonds made to CHD pretreated acid-etched dentin with commercial adhesives with water wet-bonding were preserved after 9 mos but not after 18 mos, with severe hybrid layer degradation. The results led to rejection of the null hypothesis and highlight the concept of biomimetic water replacement from the collagen intrafibrillar compartments as the ultimate goal in extending the longevity of resin-dentin bonds.

Original languageEnglish (US)
Pages (from-to)1499-1504
Number of pages6
JournalJournal of Dental Research
Volume89
Issue number12
DOIs
StatePublished - Dec 1 2010

Fingerprint

Dentin
Chlorhexidine
Ethanol
Water
Adhesives
Artificial Saliva
Biomimetics
Acids
Matrix Metalloproteinase Inhibitors
Collagen
Pressure

Keywords

  • degradation
  • dentin bonding
  • ethanol
  • hybrid layer
  • hydrophobic resin

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Ethanol wet-bonding challenges current anti-degradation strategy. / Sadek, F. T.; Braga, R. R.; Muench, A.; Liu, Y.; Pashley, David Henry; Tay, Franklin Chi Meng.

In: Journal of Dental Research, Vol. 89, No. 12, 01.12.2010, p. 1499-1504.

Research output: Contribution to journalArticle

Sadek, FT, Braga, RR, Muench, A, Liu, Y, Pashley, DH & Tay, FCM 2010, 'Ethanol wet-bonding challenges current anti-degradation strategy', Journal of Dental Research, vol. 89, no. 12, pp. 1499-1504. https://doi.org/10.1177/0022034510385240
Sadek, F. T. ; Braga, R. R. ; Muench, A. ; Liu, Y. ; Pashley, David Henry ; Tay, Franklin Chi Meng. / Ethanol wet-bonding challenges current anti-degradation strategy. In: Journal of Dental Research. 2010 ; Vol. 89, No. 12. pp. 1499-1504.
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