Evaluation of polyethylene glycol/polylactic acid films in the prevention of adhesions in the rabbit adhesion formation and reformation sidewall models

Kathleen Rodgers, Daniel Cohn, Anna Hotovely, Eli Pines, Michael Peter Diamond, Gere Dizerega

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Objective: To assess the efficacy of bioresorbable films consisting of various polyethylene glycol 6000 and polylactic acid block copolymers on the formation and reformation of adhesions in rabbit models of adhesion development between the sidewall to the adjacent cecum and bowel. The composition of the different polymers was expressed by the number of monomeric units in the block, namely, ethylene oxide (EO) and lactic acid (LA), respectively. Design: Studies of the efficacy of EO/LA films were conducted in rabbit sidewall adhesion formation studies in the presence and absence of blood and in rabbit adhesion reformation studies. REPEL (Life Medical Sciences, Edison, NJ), a film of EO/LA ratio 3.0 manufactured under commercial conditions, was also tested in these animal models. Setting: University-based laboratory. Animals: New Zealand white rabbits. Intervention(s): Placement of films of various EO/LA ratios at the site of injury to the parietal peritoneum. Main Outcome Measure(s): Adhesion formation and reformation. Result(s): Films of various EO/LA ratios, Seprafilm (Genzyme, Cambridge, MA) and Interceed (Johnson and Johnson Medical, Arlington, TX) placed over an area of excised sidewall at the time of initial injury were highly efficacious in the prevention of adhesion formation. A film of EO/LA ratio 3.7, in contrast with Interceed, was also shown to maintain maximal efficacy in the reduction of adhesion formation in the presence of blood. Further, a film of EO/LA ratio 3.0 produced under commercial conditions, REPEL, was highly efficacious in reducing adhesion development in the rabbit models of adhesion and reformation. Conclusion(s): These studies suggest that bioresorbable EO/LA films reduced adhesion development in rabbit models of adhesion formation and reformation.

Original languageEnglish (US)
Pages (from-to)403-408
Number of pages6
JournalFertility and Sterility
Volume69
Issue number3 SUPPL. 2
StatePublished - Dec 1 1998
Externally publishedYes

Fingerprint

Ethylene Oxide
Lactic Acid
Rabbits
Cecum
Biological Science Disciplines
poly(lactic acid)
Peritoneum
Wounds and Injuries
Polymers
Animal Models
Outcome Assessment (Health Care)

Keywords

  • Adhesions
  • Barrier
  • Bioresorbable
  • Polyethylene glycol
  • Polylactic acid

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Evaluation of polyethylene glycol/polylactic acid films in the prevention of adhesions in the rabbit adhesion formation and reformation sidewall models. / Rodgers, Kathleen; Cohn, Daniel; Hotovely, Anna; Pines, Eli; Diamond, Michael Peter; Dizerega, Gere.

In: Fertility and Sterility, Vol. 69, No. 3 SUPPL. 2, 01.12.1998, p. 403-408.

Research output: Contribution to journalArticle

Rodgers, Kathleen ; Cohn, Daniel ; Hotovely, Anna ; Pines, Eli ; Diamond, Michael Peter ; Dizerega, Gere. / Evaluation of polyethylene glycol/polylactic acid films in the prevention of adhesions in the rabbit adhesion formation and reformation sidewall models. In: Fertility and Sterility. 1998 ; Vol. 69, No. 3 SUPPL. 2. pp. 403-408.
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AU - Hotovely, Anna

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AU - Diamond, Michael Peter

AU - Dizerega, Gere

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AB - Objective: To assess the efficacy of bioresorbable films consisting of various polyethylene glycol 6000 and polylactic acid block copolymers on the formation and reformation of adhesions in rabbit models of adhesion development between the sidewall to the adjacent cecum and bowel. The composition of the different polymers was expressed by the number of monomeric units in the block, namely, ethylene oxide (EO) and lactic acid (LA), respectively. Design: Studies of the efficacy of EO/LA films were conducted in rabbit sidewall adhesion formation studies in the presence and absence of blood and in rabbit adhesion reformation studies. REPEL (Life Medical Sciences, Edison, NJ), a film of EO/LA ratio 3.0 manufactured under commercial conditions, was also tested in these animal models. Setting: University-based laboratory. Animals: New Zealand white rabbits. Intervention(s): Placement of films of various EO/LA ratios at the site of injury to the parietal peritoneum. Main Outcome Measure(s): Adhesion formation and reformation. Result(s): Films of various EO/LA ratios, Seprafilm (Genzyme, Cambridge, MA) and Interceed (Johnson and Johnson Medical, Arlington, TX) placed over an area of excised sidewall at the time of initial injury were highly efficacious in the prevention of adhesion formation. A film of EO/LA ratio 3.7, in contrast with Interceed, was also shown to maintain maximal efficacy in the reduction of adhesion formation in the presence of blood. Further, a film of EO/LA ratio 3.0 produced under commercial conditions, REPEL, was highly efficacious in reducing adhesion development in the rabbit models of adhesion and reformation. Conclusion(s): These studies suggest that bioresorbable EO/LA films reduced adhesion development in rabbit models of adhesion formation and reformation.

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