Evidence for metabotropic glutamate receptor activation in the induction of depolarization-induced suppression of inhibition in hippocampal CA1

Wade Morishita, Sergei A. Kirov, Bradley E. Alger

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

Depolarization-induced suppression of inhibition (DSI) is a transient reduction of GABA(A) receptor-mediated IPSCs that is mediated by a retrograde signal from principal cells to interneurons. Using whole-cell recordings, we tested the hypothesis that mGluRs are involved in the DSI process in hippocampal CA1, as has been proposed for cerebellar DSI. Group II mGluR agonists failed to affect either evoked monosynaptic IPSCs or DSI, and forskolin, which blocks cerebellar DSI, did not affect CA1 DSI. Group I and group III mGluR agonists reduced IPSCs, but only group I agonists occluded DSI. (S)-MCPG blocked (1S,3R)-ACPD-induced IPSC suppression and markedly reduced DSI, whereas group III antagonists had no effect on DSI. Many other similarities between DSI and the (1S,3R)-ACPD-induced suppression of IPSCs also were found. Our data suggest that a glutamate-like substance released from pyramidal cells could mediate CA1 DSI by reducing GABA release from interneurons via the activation of group I mGluRs.

Original languageEnglish (US)
Pages (from-to)4870-4882
Number of pages13
JournalJournal of Neuroscience
Volume18
Issue number13
DOIs
StatePublished - Jul 1 1998

Keywords

  • GABA
  • IPSP
  • MGluR
  • Retrograde signal
  • Synaptic inhibition
  • Voltage clamp

ASJC Scopus subject areas

  • Neuroscience(all)

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