Evidence for metabotropic glutamate receptor activation in the induction of depolarization-induced suppression of inhibition in hippocampal CA1

Wade Morishita, Sergei A Kirov, Bradley E. Alger

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Depolarization-induced suppression of inhibition (DSI) is a transient reduction of GABA(A) receptor-mediated IPSCs that is mediated by a retrograde signal from principal cells to interneurons. Using whole-cell recordings, we tested the hypothesis that mGluRs are involved in the DSI process in hippocampal CA1, as has been proposed for cerebellar DSI. Group II mGluR agonists failed to affect either evoked monosynaptic IPSCs or DSI, and forskolin, which blocks cerebellar DSI, did not affect CA1 DSI. Group I and group III mGluR agonists reduced IPSCs, but only group I agonists occluded DSI. (S)-MCPG blocked (1S,3R)-ACPD-induced IPSC suppression and markedly reduced DSI, whereas group III antagonists had no effect on DSI. Many other similarities between DSI and the (1S,3R)-ACPD-induced suppression of IPSCs also were found. Our data suggest that a glutamate-like substance released from pyramidal cells could mediate CA1 DSI by reducing GABA release from interneurons via the activation of group I mGluRs.

Original languageEnglish (US)
Pages (from-to)4870-4882
Number of pages13
JournalJournal of Neuroscience
Volume18
Issue number13
StatePublished - Jul 1 1998
Externally publishedYes

Fingerprint

Metabotropic Glutamate Receptors
Interneurons
Pyramidal Cells
Patch-Clamp Techniques
Colforsin
GABA-A Receptors
gamma-Aminobutyric Acid
Glutamic Acid
1-amino-1,3-dicarboxycyclopentane

Keywords

  • GABA
  • IPSP
  • MGluR
  • Retrograde signal
  • Synaptic inhibition
  • Voltage clamp

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Evidence for metabotropic glutamate receptor activation in the induction of depolarization-induced suppression of inhibition in hippocampal CA1. / Morishita, Wade; Kirov, Sergei A; Alger, Bradley E.

In: Journal of Neuroscience, Vol. 18, No. 13, 01.07.1998, p. 4870-4882.

Research output: Contribution to journalArticle

@article{4202c2ac92f34be4b1f8165e172381bd,
title = "Evidence for metabotropic glutamate receptor activation in the induction of depolarization-induced suppression of inhibition in hippocampal CA1",
abstract = "Depolarization-induced suppression of inhibition (DSI) is a transient reduction of GABA(A) receptor-mediated IPSCs that is mediated by a retrograde signal from principal cells to interneurons. Using whole-cell recordings, we tested the hypothesis that mGluRs are involved in the DSI process in hippocampal CA1, as has been proposed for cerebellar DSI. Group II mGluR agonists failed to affect either evoked monosynaptic IPSCs or DSI, and forskolin, which blocks cerebellar DSI, did not affect CA1 DSI. Group I and group III mGluR agonists reduced IPSCs, but only group I agonists occluded DSI. (S)-MCPG blocked (1S,3R)-ACPD-induced IPSC suppression and markedly reduced DSI, whereas group III antagonists had no effect on DSI. Many other similarities between DSI and the (1S,3R)-ACPD-induced suppression of IPSCs also were found. Our data suggest that a glutamate-like substance released from pyramidal cells could mediate CA1 DSI by reducing GABA release from interneurons via the activation of group I mGluRs.",
keywords = "GABA, IPSP, MGluR, Retrograde signal, Synaptic inhibition, Voltage clamp",
author = "Wade Morishita and Kirov, {Sergei A} and Alger, {Bradley E.}",
year = "1998",
month = "7",
day = "1",
language = "English (US)",
volume = "18",
pages = "4870--4882",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "13",

}

TY - JOUR

T1 - Evidence for metabotropic glutamate receptor activation in the induction of depolarization-induced suppression of inhibition in hippocampal CA1

AU - Morishita, Wade

AU - Kirov, Sergei A

AU - Alger, Bradley E.

PY - 1998/7/1

Y1 - 1998/7/1

N2 - Depolarization-induced suppression of inhibition (DSI) is a transient reduction of GABA(A) receptor-mediated IPSCs that is mediated by a retrograde signal from principal cells to interneurons. Using whole-cell recordings, we tested the hypothesis that mGluRs are involved in the DSI process in hippocampal CA1, as has been proposed for cerebellar DSI. Group II mGluR agonists failed to affect either evoked monosynaptic IPSCs or DSI, and forskolin, which blocks cerebellar DSI, did not affect CA1 DSI. Group I and group III mGluR agonists reduced IPSCs, but only group I agonists occluded DSI. (S)-MCPG blocked (1S,3R)-ACPD-induced IPSC suppression and markedly reduced DSI, whereas group III antagonists had no effect on DSI. Many other similarities between DSI and the (1S,3R)-ACPD-induced suppression of IPSCs also were found. Our data suggest that a glutamate-like substance released from pyramidal cells could mediate CA1 DSI by reducing GABA release from interneurons via the activation of group I mGluRs.

AB - Depolarization-induced suppression of inhibition (DSI) is a transient reduction of GABA(A) receptor-mediated IPSCs that is mediated by a retrograde signal from principal cells to interneurons. Using whole-cell recordings, we tested the hypothesis that mGluRs are involved in the DSI process in hippocampal CA1, as has been proposed for cerebellar DSI. Group II mGluR agonists failed to affect either evoked monosynaptic IPSCs or DSI, and forskolin, which blocks cerebellar DSI, did not affect CA1 DSI. Group I and group III mGluR agonists reduced IPSCs, but only group I agonists occluded DSI. (S)-MCPG blocked (1S,3R)-ACPD-induced IPSC suppression and markedly reduced DSI, whereas group III antagonists had no effect on DSI. Many other similarities between DSI and the (1S,3R)-ACPD-induced suppression of IPSCs also were found. Our data suggest that a glutamate-like substance released from pyramidal cells could mediate CA1 DSI by reducing GABA release from interneurons via the activation of group I mGluRs.

KW - GABA

KW - IPSP

KW - MGluR

KW - Retrograde signal

KW - Synaptic inhibition

KW - Voltage clamp

UR - http://www.scopus.com/inward/record.url?scp=0032125264&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032125264&partnerID=8YFLogxK

M3 - Article

C2 - 9634553

AN - SCOPUS:0032125264

VL - 18

SP - 4870

EP - 4882

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 13

ER -