TY - JOUR
T1 - Evolution of a normal karyotype in a mouse bladder epithelial cell line transformed in vitro
AU - Cowell, John Kenneth
PY - 1981/1/1
Y1 - 1981/1/1
N2 - An in vitro transformed, carcinoma-producing mouse bladder epithelial cell line with an apparently normal karyotype is described. This cell line has arisen as a variant from a cell line that was trisomic for chromosome #15. It was suggested that the malignant phenotype in the parental cell line results from an excess of "abnormal" chromosomes. A mechanism is discussed for the evolution of an apparently normal karyotype from an abnormal karyotype.
AB - An in vitro transformed, carcinoma-producing mouse bladder epithelial cell line with an apparently normal karyotype is described. This cell line has arisen as a variant from a cell line that was trisomic for chromosome #15. It was suggested that the malignant phenotype in the parental cell line results from an excess of "abnormal" chromosomes. A mechanism is discussed for the evolution of an apparently normal karyotype from an abnormal karyotype.
UR - http://www.scopus.com/inward/record.url?scp=0019472559&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019472559&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(81)90046-7
DO - 10.1016/0165-4608(81)90046-7
M3 - Article
C2 - 7260889
AN - SCOPUS:0019472559
VL - 3
SP - 359
EP - 361
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 4
ER -