Evolution of a normal karyotype in a mouse bladder epithelial cell line transformed in vitro

John K. Cowell

doi:10.1016/0165-4608(81)90046-7

Evolution of a normal karyotype in a mouse bladder epithelial cell line transformed in vitro

John K. Cowell

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

An in vitro transformed, carcinoma-producing mouse bladder epithelial cell line with an apparently normal karyotype is described. This cell line has arisen as a variant from a cell line that was trisomic for chromosome #15. It was suggested that the malignant phenotype in the parental cell line results from an excess of "abnormal" chromosomes. A mechanism is discussed for the evolution of an apparently normal karyotype from an abnormal karyotype.

Original language	English (US)
Pages (from-to)	359-361
Number of pages	3
Journal	Cancer Genetics and Cytogenetics
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/0165-4608(81)90046-7
State	Published - Jun 1981
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0165-4608(81)90046-7

Cite this

@article{d72cb75cc90a48a39c2a9ed4c3ece56d,

title = "Evolution of a normal karyotype in a mouse bladder epithelial cell line transformed in vitro",

abstract = "An in vitro transformed, carcinoma-producing mouse bladder epithelial cell line with an apparently normal karyotype is described. This cell line has arisen as a variant from a cell line that was trisomic for chromosome #15. It was suggested that the malignant phenotype in the parental cell line results from an excess of {"}abnormal{"} chromosomes. A mechanism is discussed for the evolution of an apparently normal karyotype from an abnormal karyotype.",

author = "Cowell, {John K.}",

year = "1981",

month = jun,

doi = "10.1016/0165-4608(81)90046-7",

language = "English (US)",

volume = "3",

pages = "359--361",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Evolution of a normal karyotype in a mouse bladder epithelial cell line transformed in vitro

AU - Cowell, John K.

PY - 1981/6

Y1 - 1981/6

N2 - An in vitro transformed, carcinoma-producing mouse bladder epithelial cell line with an apparently normal karyotype is described. This cell line has arisen as a variant from a cell line that was trisomic for chromosome #15. It was suggested that the malignant phenotype in the parental cell line results from an excess of "abnormal" chromosomes. A mechanism is discussed for the evolution of an apparently normal karyotype from an abnormal karyotype.

AB - An in vitro transformed, carcinoma-producing mouse bladder epithelial cell line with an apparently normal karyotype is described. This cell line has arisen as a variant from a cell line that was trisomic for chromosome #15. It was suggested that the malignant phenotype in the parental cell line results from an excess of "abnormal" chromosomes. A mechanism is discussed for the evolution of an apparently normal karyotype from an abnormal karyotype.

UR - http://www.scopus.com/inward/record.url?scp=0019472559&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019472559&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(81)90046-7

DO - 10.1016/0165-4608(81)90046-7

M3 - Article

C2 - 7260889

AN - SCOPUS:0019472559

SN - 0165-4608

VL - 3

SP - 359

EP - 361

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 4

ER -

Evolution of a normal karyotype in a mouse bladder epithelial cell line transformed in vitro

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this