Evolution of a normal karyotype in a mouse bladder epithelial cell line transformed in vitro

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An in vitro transformed, carcinoma-producing mouse bladder epithelial cell line with an apparently normal karyotype is described. This cell line has arisen as a variant from a cell line that was trisomic for chromosome #15. It was suggested that the malignant phenotype in the parental cell line results from an excess of "abnormal" chromosomes. A mechanism is discussed for the evolution of an apparently normal karyotype from an abnormal karyotype.

Original languageEnglish (US)
Pages (from-to)359-361
Number of pages3
JournalCancer Genetics and Cytogenetics
Volume3
Issue number4
DOIs
StatePublished - Jan 1 1981
Externally publishedYes

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Karyotype
Urinary Bladder
Epithelial Cells
Cell Line
Abnormal Karyotype
Chromosomes, Human, Pair 15
Chromosomes
Carcinoma
Phenotype
In Vitro Techniques

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Evolution of a normal karyotype in a mouse bladder epithelial cell line transformed in vitro. / Cowell, John Kenneth.

In: Cancer Genetics and Cytogenetics, Vol. 3, No. 4, 01.01.1981, p. 359-361.

Research output: Contribution to journalArticle

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