Abstract
An in vitro transformed, carcinoma-producing mouse bladder epithelial cell line with an apparently normal karyotype is described. This cell line has arisen as a variant from a cell line that was trisomic for chromosome #15. It was suggested that the malignant phenotype in the parental cell line results from an excess of "abnormal" chromosomes. A mechanism is discussed for the evolution of an apparently normal karyotype from an abnormal karyotype.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 359-361 |
| Number of pages | 3 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 3 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research
Cite this
Evolution of a normal karyotype in a mouse bladder epithelial cell line transformed in vitro. / Cowell, John Kenneth.
In: Cancer Genetics and Cytogenetics, Vol. 3, No. 4, 01.01.1981, p. 359-361.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evolution of a normal karyotype in a mouse bladder epithelial cell line transformed in vitro
AU - Cowell, John Kenneth
PY - 1981/1/1
Y1 - 1981/1/1
N2 - An in vitro transformed, carcinoma-producing mouse bladder epithelial cell line with an apparently normal karyotype is described. This cell line has arisen as a variant from a cell line that was trisomic for chromosome #15. It was suggested that the malignant phenotype in the parental cell line results from an excess of "abnormal" chromosomes. A mechanism is discussed for the evolution of an apparently normal karyotype from an abnormal karyotype.
AB - An in vitro transformed, carcinoma-producing mouse bladder epithelial cell line with an apparently normal karyotype is described. This cell line has arisen as a variant from a cell line that was trisomic for chromosome #15. It was suggested that the malignant phenotype in the parental cell line results from an excess of "abnormal" chromosomes. A mechanism is discussed for the evolution of an apparently normal karyotype from an abnormal karyotype.
UR - http://www.scopus.com/inward/record.url?scp=0019472559&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019472559&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(81)90046-7
DO - 10.1016/0165-4608(81)90046-7
M3 - Article
C2 - 7260889
AN - SCOPUS:0019472559
VL - 3
SP - 359
EP - 361
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 4
ER -