Excitatory amino acid regulation of gonadotropin secretion: modulation by steroid hormones

Darrell W Brann, Virendra B. Mahesh

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Excitatory amino acids (EAAs) can potently modulate gonadotropin secretion in the male rat and monkey. In the present study we examined of EAAs on luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the female rat under low estrogen (ovariectomized) and high estrogen (proestrus) backgrounds. In ovariectomized immature female rats N-methyl-D-aspartate (NMDA) inhibited LH but not FSH secretion at 30 min post-injection. In contrast, NMDA potently stimulated LH but not FSH secretion when administered on proestrus to adult female rats. Both glutamate and kainate were also found to stimulate LH but not FSH secretion in estrogen-treated ovariectomized immature rats. This study suggests that EAA neurotransmission may be an important component in the expression of gonadotropin surges and that EAA effects appear to be subject to gonadal steroid regulation.

Original languageEnglish (US)
Pages (from-to)847-850
Number of pages4
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume41
Issue number3-8
DOIs
StatePublished - Jan 1 1992

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Steroid hormones
Excitatory Amino Acids
Gonadotropins
Follicle Stimulating Hormone
Rats
Luteinizing Hormone
Steroids
Modulation
Hormones
Proestrus
Estrogens
N-Methylaspartate
Excitatory Amino Acid Agents
Kainic Acid
Synaptic Transmission
Haplorhini
Glutamic Acid
Injections

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Excitatory amino acid regulation of gonadotropin secretion : modulation by steroid hormones. / Brann, Darrell W; Mahesh, Virendra B.

In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 41, No. 3-8, 01.01.1992, p. 847-850.

Research output: Contribution to journalArticle

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