Exploring magnetohydrodynamic voltage distributions in the human body: Preliminary results

T. Stan Gregory, Jonathan R Murrow, John N. Oshinski, Zion Tsz Ho Tse

Research output: Contribution to journalArticle

Abstract

Background The aim of this study was to noninvasively measure regional contributions of vasculature in the human body using magnetohydrodynamic voltages (V MHD ) obtained from electrocardiogram (ECG) recordings performed inside MRI’s static magnetic field (B 0 ). Integrating the regional V MHD over the S wave -T wave segment of the cardiac cycle (V segment ) provides a noninvasive method for measuring regional blood volumes, which can be rapidly obtained during MRI without incurring additional cost. Methods V MHD was extracted from 12-lead ECG traces acquired during gradual introduction into a 3T MRI. Regional contributions were computed utilizing weights based on B 0 ’s strength at specified distances from isocenter. V segment mapping was performed in six subjects and validated against MR angiograms (MRA). Results Fluctuations in V segment , which presented as positive trace deflections, were found to be associated with aortic-arch flow in the thoracic cavity, the main branches of the abdominal aorta, and the bifurcation of the common iliac artery. The largest fluctuation corresponded to the location where the aortic arch was approximately orthogonal to B 0 . The smallest fluctuations corresponded to areas of vasculature that were parallel to B 0 . Significant correlations (specifically, Spearman’s ranked correlation coefficients of 0.96 and 0.97 for abdominal and thoracic cavities, respectively) were found between the MRA and V segment maps (p < 0.001). Conclusions A novel non-invasive method to extract regional blood volumes from ECGs was developed and shown to be a rapid means to quantify peripheral and abdominal blood volumes.

Original languageEnglish (US)
Article numbere0213235
JournalPloS one
Volume14
Issue number3
DOIs
StatePublished - Mar 1 2019
Externally publishedYes

Fingerprint

blood volume
Magnetohydrodynamics
Blood Volume
Human Body
Thoracic Cavity
thoracic cavity
Electrocardiography
electrocardiography
Magnetic resonance imaging
Thoracic Aorta
Blood
Angiography
Electric potential
Arches
iliac artery
abdominal cavity
Abdominal Cavity
Iliac Artery
Abdominal Aorta
Magnetic Fields

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Exploring magnetohydrodynamic voltage distributions in the human body : Preliminary results. / Stan Gregory, T.; Murrow, Jonathan R; Oshinski, John N.; Ho Tse, Zion Tsz.

In: PloS one, Vol. 14, No. 3, e0213235, 01.03.2019.

Research output: Contribution to journalArticle

Stan Gregory, T. ; Murrow, Jonathan R ; Oshinski, John N. ; Ho Tse, Zion Tsz. / Exploring magnetohydrodynamic voltage distributions in the human body : Preliminary results. In: PloS one. 2019 ; Vol. 14, No. 3.
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