Fine-mapping of the type 1 diabetes locus (IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses

Sarah Eckenrode, Michele P. Marron, Robert Nicholls, Mark C.K. Yang, James J. Yang, Leticia C. Guida Fonseca, Jin-Xiong She

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Abstract

Previous studies have identified a susceptibility region for insulin-dependent (type I) diabetes mellitus on chromosome 11q13 (IDDM4). In this study, 15 polymorphic markers were analyzed for 382 affected sibpair (ASP) families with type 1 diabetes. Our analyses provided additional evidence for linkage for IDDM4 (a peak LOD score of 3.4 at D11S913). The markers with strong linkage evidence are located within an interval of approximately 6 cM between, D11S4205 and GALN. We also identified polymorphisms in two candidate genes, Fas-associated death domain protein (FADD) and galanin (GALN). Analyses of the data by transmission/disequilibrium test (TDT) and extended TDT (ETDT) did not provide any evidence for association/linkage with these candidate genes. However, ETDT did reveal significant association/linkage with the marker D11S987 (P = 0.0004) within the IDDM4 interval defined by ASP analyses, suggesting that IDDM4 may be in the close proximity of D11S987.

Original languageEnglish (US)
Pages (from-to)14-18
Number of pages5
JournalHuman Genetics
Volume106
Issue number1
DOIs
StatePublished - Jan 1 2000

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Fas-Associated Death Domain Protein
Galanin
Linkage Disequilibrium
Type 1 Diabetes Mellitus
Chromosomes
Genes
Insulin-Dependent Diabetes Mellitus 4

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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Fine-mapping of the type 1 diabetes locus (IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses. / Eckenrode, Sarah; Marron, Michele P.; Nicholls, Robert; Yang, Mark C.K.; Yang, James J.; Guida Fonseca, Leticia C.; She, Jin-Xiong.

In: Human Genetics, Vol. 106, No. 1, 01.01.2000, p. 14-18.

Research output: Contribution to journalArticle

Eckenrode, Sarah ; Marron, Michele P. ; Nicholls, Robert ; Yang, Mark C.K. ; Yang, James J. ; Guida Fonseca, Leticia C. ; She, Jin-Xiong. / Fine-mapping of the type 1 diabetes locus (IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses. In: Human Genetics. 2000 ; Vol. 106, No. 1. pp. 14-18.
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abstract = "Previous studies have identified a susceptibility region for insulin-dependent (type I) diabetes mellitus on chromosome 11q13 (IDDM4). In this study, 15 polymorphic markers were analyzed for 382 affected sibpair (ASP) families with type 1 diabetes. Our analyses provided additional evidence for linkage for IDDM4 (a peak LOD score of 3.4 at D11S913). The markers with strong linkage evidence are located within an interval of approximately 6 cM between, D11S4205 and GALN. We also identified polymorphisms in two candidate genes, Fas-associated death domain protein (FADD) and galanin (GALN). Analyses of the data by transmission/disequilibrium test (TDT) and extended TDT (ETDT) did not provide any evidence for association/linkage with these candidate genes. However, ETDT did reveal significant association/linkage with the marker D11S987 (P = 0.0004) within the IDDM4 interval defined by ASP analyses, suggesting that IDDM4 may be in the close proximity of D11S987.",
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