TY - JOUR
T1 - Fluoride absorption from the rat urinary bladder
T2 - a pH dependent event
AU - Whitford, G. M.
AU - Pashley, D. H.
AU - Reynolds, K. E.
PY - 1977/1/1
Y1 - 1977/1/1
N2 - Urinary bladder absorption of stable and radiofluoride was studied as a function of pH in anesthetized rats to further evaluate the influence of pH gradients on fluoride transport. Buffered pH values and stable fluoride concentrations ranged from 1.85 to 7.90 and from 0.012 to 8.81 mM, respectively. [14C] inulin served as a marker for solute concentration changes due to water migration or dilution. The results indicate that bladder fluoride absorption is inversely related to pH over the 1.85-5.50 range. Mean, 15 min radiofluoride absorption values of 70% at pH 1.85, 37% at pH 3.95, and 5% at pH 5.50 were observed. These fractional absorption values were not significantly influenced by carrier fluoride concentration, the buffers used, or the presence of urine. Above pH 5.50, pH independent absorption occurs to a slight extent. The results are consistent with a first order absorptive process which occurs by the nonionic diffusion of hydrogen fluoride.
AB - Urinary bladder absorption of stable and radiofluoride was studied as a function of pH in anesthetized rats to further evaluate the influence of pH gradients on fluoride transport. Buffered pH values and stable fluoride concentrations ranged from 1.85 to 7.90 and from 0.012 to 8.81 mM, respectively. [14C] inulin served as a marker for solute concentration changes due to water migration or dilution. The results indicate that bladder fluoride absorption is inversely related to pH over the 1.85-5.50 range. Mean, 15 min radiofluoride absorption values of 70% at pH 1.85, 37% at pH 3.95, and 5% at pH 5.50 were observed. These fractional absorption values were not significantly influenced by carrier fluoride concentration, the buffers used, or the presence of urine. Above pH 5.50, pH independent absorption occurs to a slight extent. The results are consistent with a first order absorptive process which occurs by the nonionic diffusion of hydrogen fluoride.
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M3 - Article
C2 - 13661
AN - SCOPUS:0017369376
SN - 0363-6135
VL - 232
SP - 145
EP - 146
JO - American Journal of Physiology
JF - American Journal of Physiology
IS - 1
ER -