Fluoride pharmacokinetics during acid-base balance changes in man

J. Ekstrand, M. Ehrnebo, G. M. Whitford, P. O. Järnberg

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Five healthy subjects were each given fluoride 3.0 mg (F) as sodium fluoride tablets on two occasions - during production of acid urine, induced by giving NH4Cl, and during production of alkaline urine obtained by giving NaHCO3. Frequent plasma and urine samples were taken up to 12 h and were analyzed with a F- sensitive electrode. Control experiments without F administrations were also performed to permit calculation of net F concentration in plasma and urine. The urine F excretion was lower during acid than alkaline diuresis. Pharmacokinetic analysis of the net plasma F concentrations showed that the apparent plasma half-life of F was longer when urine was acid (4.3±0.6 h: SD; n=5) than when it was alkaline (2.4±0.4 h). This could be explained by changes in the renal clearance of F, which was always lower with an acid (61.5±8.1 ml/min) than an alkaline (97.8±10.4 ml/min) urine. The apparent extra-renal clearance, which mainly represents clearance to the bone-pool, was also significantly higher during production of alkaline (109.2±20.2 ml/min) than of acid (86.3±21.3 ml/min) urine. It is suggested, that increased reabsorption of non-ionic hydrogen fluoride (HF) is responsible for the decreased renal clearance during acidic conditions.

Original languageEnglish (US)
Pages (from-to)189-194
Number of pages6
JournalEuropean Journal of Clinical Pharmacology
Volume18
Issue number2
DOIs
StatePublished - Mar 1 1980
Externally publishedYes

Keywords

  • fluoride
  • fluoride kinetics
  • renal clearance
  • urinary pH

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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