Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain

Nagendran Muthusamy, Andrew Brumm, Xuying Zhang, S. Thomas Carmichael, H. Troy Ghashghaei

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The stem cell source of neural and glial progenitors in the periventricular regions of the adult forebrain has remained uncertain and controversial. Using a cell specific genetic approach we rule out Foxj1+ ependymal cells as stem cells participating in neurogenesis and gliogenesis in response to acute injury or stroke in the mouse forebrain. Non stem-And progenitor-like responses of Foxj1+ ependymal cells to injury and stroke remain to be defined and investigated.

Original languageEnglish (US)
Article number1766
JournalScientific reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018
Externally publishedYes

ASJC Scopus subject areas

  • General

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