FSH receptor (FSHR) expression in human extragonadal reproductive tissues and the developing placenta, and the impact of its deletion on pregnancy in mice

Julie A.W. Stilley, Debora E. Christensen, Kristin B. Dahlem, Rongbin Guan, Donna A. Santillan, Sarah K. England, Ayman Al-Hendy, Patricia A. Kirby, Deborah L. Segaloff

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Expression and function of the follicle-stimulating hormone receptor (FSHR) in females were long thought to be limited to the ovary. Here, however, we identify extragonadal FSHR in both the human female reproductive tract and the placenta, and test its physiological relevance in mice. We show that in nonpregnant women FSHR is present on: endothelial cells of blood vessels in the endometrium, myometrium, and cervix; endometrial glands of the proliferative and secretory endometrium; cervical glands and the cervical stroma; and (at low levels) stromal cells and muscle fibers of the myometrium. In pregnant women, placental FSHR was detected as early as 8-10 wk of gestation and continued through term. It was expressed on: endothelial cells in fetal portions of the placenta and the umbilical cord; epithelial cells of the amnion; decidualized cells surrounding the maternal arteries in the maternal decidua; and the stromal cells and muscle fibers of the myometrium, with particularly strong expression at term. These findings suggest that FSHR expression is upregulated during decidualization and upregulated in myometrium as a function of pregnancy. The presence of FSHR in the placental vasculature suggests a role in placental angiogenesis. Analysis of genetically modified mice in which Fshr is lacking in fetal portions of the placenta revealed adverse effects on fetoplacental development. Our data further demonstrate FSHB and CGA mRNAs in placenta and uterus, consistent with potential local sources of FSH. Collectively, our data suggest heretofore unappreciated roles of extragonadal FSHR in female reproductive physiology.

Original languageEnglish (US)
Article number74
JournalBiology of reproduction
Volume91
Issue number3
DOIs
StatePublished - Sep 1 2014

Fingerprint

FSH Receptors
Placenta
Myometrium
Pregnancy
Stromal Cells
Endometrium
Endothelial Cells
Mothers
Decidua
Muscles
Amnion
Umbilical Cord
Cervix Uteri
Uterus
Blood Vessels
Pregnant Women
Ovary
Arteries
Epithelial Cells
Messenger RNA

Keywords

  • Cervix
  • FSH receptor
  • Follicle-stimulating hormone
  • Gonadotropin
  • Placenta
  • Pregnancy
  • Uterus

ASJC Scopus subject areas

  • Cell Biology

Cite this

FSH receptor (FSHR) expression in human extragonadal reproductive tissues and the developing placenta, and the impact of its deletion on pregnancy in mice. / Stilley, Julie A.W.; Christensen, Debora E.; Dahlem, Kristin B.; Guan, Rongbin; Santillan, Donna A.; England, Sarah K.; Al-Hendy, Ayman; Kirby, Patricia A.; Segaloff, Deborah L.

In: Biology of reproduction, Vol. 91, No. 3, 74, 01.09.2014.

Research output: Contribution to journalArticle

Stilley, JAW, Christensen, DE, Dahlem, KB, Guan, R, Santillan, DA, England, SK, Al-Hendy, A, Kirby, PA & Segaloff, DL 2014, 'FSH receptor (FSHR) expression in human extragonadal reproductive tissues and the developing placenta, and the impact of its deletion on pregnancy in mice', Biology of reproduction, vol. 91, no. 3, 74. https://doi.org/10.1095/biolreprod.114.118562
Stilley, Julie A.W. ; Christensen, Debora E. ; Dahlem, Kristin B. ; Guan, Rongbin ; Santillan, Donna A. ; England, Sarah K. ; Al-Hendy, Ayman ; Kirby, Patricia A. ; Segaloff, Deborah L. / FSH receptor (FSHR) expression in human extragonadal reproductive tissues and the developing placenta, and the impact of its deletion on pregnancy in mice. In: Biology of reproduction. 2014 ; Vol. 91, No. 3.
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