Functional alterations in NO, PGI2 and EDHF pathways in the aortic endothelium after myocardial infarction in rats

Gabor Csanyi, Michael Bauer, Wolfgang Dietl, Magdalena Lomnicka, Tatiana Stepuro, Bruno K. Podesser, Stefan Chlopicki

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background: Previous work on endothelial dysfunction in post-MI heart failure has shown conflicting results. Aim: To analyze gender related alterations in NO-, PGI2- and EDHF-dependent endothelial function in the thoracic aorta 7 and 42 days after myocardial infarction (MI). Methods and results: MI was induced by coronary artery ligation in female and male Sprague-Dawley rats. There was no gender related difference in infarct-size or in the impairment of fractional shortening of the left ventricle 42 days after coronary ligation. Neither acetylcholine-induced (Ach) vasodilation nor basal PGI2 production in the aorta was modified by coronary ligation. Interestingly, 7 days after MI, basal NO production was impaired and the EDHF component of Ach-induced vasodilation was up-regulated, in both male and female rats. However, 42 days post-MI, basal NO was only impaired in male rats, while EDHF was only up-regulated in female rats. Conclusion: MI induced impairment of functional activity of basal NO production and adaptive up-regulation of the EDHF component of Ach-induced relaxation. The above alterations in endothelial function in the aorta were gender-specific at 42 days but not 7 days after MI. Some of the previously reported discrepancies in the development of endothelial dysfunction in the post-MI period may be gender related differences.

Original languageEnglish (US)
Pages (from-to)769-776
Number of pages8
JournalEuropean Journal of Heart Failure
Volume8
Issue number8
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

Keywords

  • EDHF
  • Endothelial dysfunction
  • Gender
  • Heart failure
  • NO
  • PGI

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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