Functional and Molecular Insights of Hydrogen Sulfide Signaling and Protein Sulfhydration

Nilkantha Sen

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

Hydrogen sulfide (H2S), a novel gasotransmitter, is endogenously synthesized by multiple enzymes that are differentially expressed in the peripheral tissues and central nervous systems. H2S regulates a wide range of physiological processes, namely cardiovascular, neuronal, immune, respiratory, gastrointestinal, liver, and endocrine systems, by influencing cellular signaling pathways and sulfhydration of target proteins. This review focuses on the recent progress made in H2S signaling that affects mechanistic and functional aspects of several biological processes such as autophagy, inflammation, proliferation and differentiation of stem cell, cell survival/death, and cellular metabolism under both physiological and pathological conditions. Moreover, we highlighted the cross-talk between nitric oxide and H2S in several bilogical contexts.

Original languageEnglish (US)
Pages (from-to)543-561
Number of pages19
JournalJournal of Molecular Biology
Volume429
Issue number4
DOIs
StatePublished - Feb 17 2017

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Gasotransmitters
Cardiovascular Physiological Phenomena
Biological Phenomena
Hydrogen Sulfide
Endocrine System
Autophagy
Peripheral Nervous System
Cell Survival
Nitric Oxide
Cell Death
Stem Cells
Central Nervous System
Inflammation
Liver
Enzymes
Proteins

Keywords

  • CBS
  • CSE
  • hydrogen sulfide
  • sulfhydration

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Functional and Molecular Insights of Hydrogen Sulfide Signaling and Protein Sulfhydration. / Sen, Nilkantha.

In: Journal of Molecular Biology, Vol. 429, No. 4, 17.02.2017, p. 543-561.

Research output: Contribution to journalReview article

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