Functional Brain Connectivity Revealed by Sparse Coding of Large-Scale Local Field Potential Dynamics

Han Wang, Kun Xie, Li Xie, Xiang Li, Meng Li, Cheng Lyu, Hanbo Chen, Yaowu Chen, Xuesong Liu, Joseph Zhuo Tsien, Tianming Liu

Research output: Contribution to journalArticle

Abstract

Exploration of brain dynamics patterns has attracted increasing attention due to its fundamental significance in understanding the working mechanism of the brain. However, due to the lack of effective modeling methods, how the simultaneously recorded LFP can inform us about the brain dynamics remains a general challenge. In this paper, we propose a novel sparse coding based method to investigate brain dynamics of freely-behaving mice from the perspective of functional connectivity, using super-long local field potential (LFP) recordings from 13 distinct regions of the mouse brain. Compared with surrogate datasets, six and four reproducible common functional connectivities were discovered to represent the space of brain dynamics in the frequency bands of alpha and theta respectively. Modeled by a finite state machine, temporal transition framework of functional connectivities was inferred for each frequency band, and evident preference was discovered. Our results offer a novel perspective for analyzing neural recording data at such high temporal resolution and recording length, as common functional connectivities and their transition framework discovered in this work reveal the nature of the brain dynamics in freely behaving mice.

Original languageEnglish (US)
Pages (from-to)255-270
Number of pages16
JournalBrain Topography
Volume32
Issue number2
DOIs
StatePublished - Mar 30 2019

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Keywords

  • Brain dynamics
  • Freely behaving
  • Local field potential (LFP)
  • Sparse coding
  • Volume conduction

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Functional Brain Connectivity Revealed by Sparse Coding of Large-Scale Local Field Potential Dynamics. / Wang, Han; Xie, Kun; Xie, Li; Li, Xiang; Li, Meng; Lyu, Cheng; Chen, Hanbo; Chen, Yaowu; Liu, Xuesong; Tsien, Joseph Zhuo; Liu, Tianming.

In: Brain Topography, Vol. 32, No. 2, 30.03.2019, p. 255-270.

Research output: Contribution to journalArticle

Wang, H, Xie, K, Xie, L, Li, X, Li, M, Lyu, C, Chen, H, Chen, Y, Liu, X, Tsien, JZ & Liu, T 2019, 'Functional Brain Connectivity Revealed by Sparse Coding of Large-Scale Local Field Potential Dynamics', Brain Topography, vol. 32, no. 2, pp. 255-270. https://doi.org/10.1007/s10548-018-0682-3
Wang, Han ; Xie, Kun ; Xie, Li ; Li, Xiang ; Li, Meng ; Lyu, Cheng ; Chen, Hanbo ; Chen, Yaowu ; Liu, Xuesong ; Tsien, Joseph Zhuo ; Liu, Tianming. / Functional Brain Connectivity Revealed by Sparse Coding of Large-Scale Local Field Potential Dynamics. In: Brain Topography. 2019 ; Vol. 32, No. 2. pp. 255-270.
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