Fundic balloon distension stimulates antral and duodenal motility in man

Satish S.C. Rao, Sreevani Vemuri, Brenton Harris, Konrad Schulze

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Distension of the intestine triggers the peristaltic reflex, which consists of orad contraction and aborad relaxation. Whether a similar response occurs in the human stomach is unclear. Our aim was to investigate the antral and duodenal motor response(s) to mechanical distension of the proximal stomach. In six healthy volunteers, a large compliant balloon was placed in the proximal stomach. Alongside this a water-perfused manometry probe with six sensors was placed to measure the antral and duodenal motility. Pressure activity was assessed before and during balloon distension. In five of six subjects, balloon distension triggered a salvo of antral pressure waves within 3-5 min, some of which propagated into the duodenum. The amplitude of waves was higher (P < 0.05) at the antrum than at the duodenum. The area under the curve of pressure waves was higher (P < 0.05) at the antrum than at the duodenum. In conclusion, distension of the proximal stomach, at or below the threshold for perception, evokes phasic motor activity in the antrum and duodenum. Thus, the gastric response to distension differs from that observed during the intestinal peristaltic reflex.

Original languageEnglish (US)
Pages (from-to)1015-1019
Number of pages5
JournalDigestive Diseases and Sciences
Volume47
Issue number5
DOIs
Publication statusPublished - Jan 1 2002
Externally publishedYes

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Keywords

  • Compliant balloon
  • Distension
  • Pressure activity

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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