GANGLIOSIDE ABNORMALITIES IN MULTIPLE SCLEROSIS

R. K. Yu, R. W. Ledeen, L. F. Eng

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Abstract— Gangliosides were isolated from plaque tissue and normal appearing white matter of multiple sclerosis (MS) brain. All four plaques showed decreased ganglioside concn relative to normal human white matter on a wet wt basis, but significant elevation in terms of dry wt. The wet wt and dry wt concn of MS white matter gangliosides showed smaller but statistically significant decreases below normal. Thin‐layer patterns of the plaques showed several departures from normal white matter, including decrease of G4 and G5, and complete loss of G7 (sialosylgalactosylceramide). Most of the plaques had significant elevation of G2A and G3A along with increases of the slower‐migrating polysialogangliosides. An additional ganglioside was present between G2 and G2A which was not seen in normal white matter. The TLC pattern of MS white matter gangliosides was essentially normal. The evidence for a general decrease of acidic lipids within normal appearing white matter is discussed.

Original languageEnglish (US)
Pages (from-to)169-174
Number of pages6
JournalJournal of Neurochemistry
Volume23
Issue number1
DOIs
StatePublished - Jan 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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