Ganglioside content and pattern in human gliomas in culture - Correlation of morphological changes with altered gangliosides

L. Manuelidis, R. K. Yu, E. E. Manuelidis

Research output: Contribution to journalArticle

37 Scopus citations


The ganglioside level and pattern of human gliomas in monolayer cultures were examined. These gliomas revealed morphological variations that correlated with several features of ganglioside analysis. Glioblastoma lines TC 178 and TC 501 that morphologically had changed during extended subculture revealed reduced amounts and a simplified pattern of gangliosides with almost total loss of the characteristic brain complex gangliosides. In contrast, two glioblastoma lines TC 526 and TC 593, as well as the oligodendroglioma line TC 620 showed brain-like gangliosides and the cells in these cultures had maintained their characteristic morphology observed during early subcultures. The possibility that altered ganglioside levels occur in conjunction with morphological changes after propagation in vitro is discussed.

Original languageEnglish (US)
Pages (from-to)129-135
Number of pages7
JournalActa Neuropathologica
Issue number2
Publication statusPublished - Jan 1 1977
Externally publishedYes



  • Gangliosides
  • Glial tumors
  • Scanning electron microscopy
  • Tissue culture

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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