Ganglioside GD3: structure, cellular distribution, and possible function

Thomas N. Seyfrieda, Robert K Yu

Research output: Contribution to journalReview article

100 Scopus citations

Abstract

Insight on the function of gangliosides. can emerge from knowledge of their cellular distribution. In this paper we review the structure of ganglioside GD3 and recent information on its cellular distribution. GD3 appears to be enriched in a variety of neural cell types including: reactive glia, gliomas, undifferentiated neurons, Muller glia, and oligodendroglia. Because each of these cell types share an enhanced permeability to ions and metabolites or possess properties associated with enhanced permeability, we suggest that GD3 is associated with enhanced membrane permeability. A possible function for GD3 in membrane permeability has implications for other cellular events such as metabolism, growth and interactions.

Original languageEnglish (US)
Pages (from-to)3-10
Number of pages8
JournalMolecular and Cellular Biochemistry
Volume68
Issue number1
DOIs
StatePublished - Sep 1 1985
Externally publishedYes

Keywords

  • development
  • gangliosides
  • gliomas
  • membrane permeability
  • mutant mice
  • reactive glia

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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