GANGLIOSIDES IN DEVELOPING MOUSE BRAIN MYELIN

Robert K Yu, S. I. Yen

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Abstract— Gangliosides were isolated from myelin prepared from mouse brains of different ages (23 to 490 days). Quantitative estimation of lipid‐bound sialic acid levels indicated a gradual increase from 560 μg/g of myelin at 23 days to about 1200 μg/g of myelin at older ages. The major ganglioside in all myelin preparations was the monosialoganglioside G4 (GM1). However, considerable amounts of di‐ and trisialo species also were found in myelin from young animals. In contrast to human myelin in which the monosialoganglioside, sialosylgalactosylceramide (G7) was highly enriched (Ledeenet al., 1973), a much smaller enrichment of this ganglioside was noticed in mouse brain myelin. Ganglioside G7 was not detectable in myelin until the animals were 35 days old, and showed a slight increase with increasing age after that. The results strongly indicated that the concentration of G7 in myelin is species specific and age dependent. The study also demonstrated that the ganglioside accretion in developing mouse brain myelin was attributable to the enrichment of monosialogangliosides G4 (GM1), G5 (GM2) and G7 at the expense of polysialogangliosides.

Original languageEnglish (US)
Pages (from-to)229-232
Number of pages4
JournalJournal of Neurochemistry
Volume25
Issue number3
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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